TY - JOUR
T1 - Cartilage regeneration
AU - Boyan, Barbara D.
AU - Dean, David D.
AU - Lohmann, Christoph H.
AU - Niederauer, Gabriele G.
AU - McMillan, Jacquelyn
AU - Sylvia, Victor L.
AU - Schwartz, Zvi
N1 - Funding Information:
The authors thank Sandra Messier for her assistance in the preparation of the manuscript, and they acknowledge the support of the National Institutes of Health (US PHS grants DE-08603 and DE-05937). The authors also thank Dr. Frank Barry, Osiris Therapeutics, Inc. (Baltimore, MD) for his assistance in the preparation of the manuscript; Smith and Nephew (Andover, MA) for their contribution of Fig. 2 ; and OsteoBiologics, Inc. (San Antonio, TX) for their contribution of Figs. 3 and 4 .
PY - 2002
Y1 - 2002
N2 - This article has shown the problems and challenges of tissue engineering cartilage and has presented the current strategies that are under investigation. The specific characteristics of the tissue are advantages and disadvantages. Surgeries can be performed arthroscopically, but the lack of a robust intrinsic healing response hampers the effectiveness of the therapy. We have not yet solved the problem of the choice of cells, nor have we identified all of the requisites for optimal scaffold design. Efforts thus far have focused on small defects in relatively healthy patients. How aging, disease, and pharmacologic intervention will modify the effectiveness of tissue-engineered cartilage, whether it is produced in vivo or ex vivo, is still unknown. Despite the problems, the advances made over the past 5 years suggest that the challenges will be met.
AB - This article has shown the problems and challenges of tissue engineering cartilage and has presented the current strategies that are under investigation. The specific characteristics of the tissue are advantages and disadvantages. Surgeries can be performed arthroscopically, but the lack of a robust intrinsic healing response hampers the effectiveness of the therapy. We have not yet solved the problem of the choice of cells, nor have we identified all of the requisites for optimal scaffold design. Efforts thus far have focused on small defects in relatively healthy patients. How aging, disease, and pharmacologic intervention will modify the effectiveness of tissue-engineered cartilage, whether it is produced in vivo or ex vivo, is still unknown. Despite the problems, the advances made over the past 5 years suggest that the challenges will be met.
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U2 - 10.1016/S1042-3699(02)00017-1
DO - 10.1016/S1042-3699(02)00017-1
M3 - Review article
C2 - 18088614
AN - SCOPUS:0036331284
SN - 1042-3699
VL - 14
SP - 105
EP - 116
JO - Oral and Maxillofacial Surgery Clinics of North America
JF - Oral and Maxillofacial Surgery Clinics of North America
IS - 1
ER -