Cartilage regeneration

Barbara D. Boyan, David D. Dean, Christoph H. Lohmann, Gabriele G. Niederauer, Jacquelyn McMillan, Victor L. Sylvia, Zvi Schwartz

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

This article has shown the problems and challenges of tissue engineering cartilage and has presented the current strategies that are under investigation. The specific characteristics of the tissue are advantages and disadvantages. Surgeries can be performed arthroscopically, but the lack of a robust intrinsic healing response hampers the effectiveness of the therapy. We have not yet solved the problem of the choice of cells, nor have we identified all of the requisites for optimal scaffold design. Efforts thus far have focused on small defects in relatively healthy patients. How aging, disease, and pharmacologic intervention will modify the effectiveness of tissue-engineered cartilage, whether it is produced in vivo or ex vivo, is still unknown. Despite the problems, the advances made over the past 5 years suggest that the challenges will be met.

Original languageEnglish (US)
Pages (from-to)105-116
Number of pages12
JournalOral and Maxillofacial Surgery Clinics of North America
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2002

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ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

Cite this

Boyan, B. D., Dean, D. D., Lohmann, C. H., Niederauer, G. G., McMillan, J., Sylvia, V. L., & Schwartz, Z. (2002). Cartilage regeneration. Oral and Maxillofacial Surgery Clinics of North America, 14(1), 105-116. https://doi.org/10.1016/S1042-3699(02)00017-1