Carrageenan-induced inflammation alters the content of i-cGMP and i-cAMP in the dorsal horn of the spinal cord

Mary G. Garry; Jennelle Durnett Richardson; Kenneth M. Hargreaves

doi:10.1016/0006-8993(94)90066-3

Carrageenan-induced inflammation alters the content of i-cGMP and i-cAMP in the dorsal horn of the spinal cord

Mary G. Garry, Jennelle Durnett Richardson, Kenneth M. Hargreaves

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Hindpaw injections of carrageenan (CARRA) decreased paw withdrawal latencies to radiant heat and increased hindpaw edema. At the peak of hyperalgesia, the content of immunoreactive guanosine 3′,5′-cyclic monophosphate (i-cGMP) was increased, while immunoreactive adenosine 3′,5′-cyclic monophosphate (i-cAMP) was decreased in lumbar, but not cervical dorsal horn. In general, the content of i-cGMP in the dorsal horn was correlated with thermal hyperalgesia throughout the course of this model. These results indicate that a peripheral inflammation alters the content of i-cGMP and i-cAMP in the spinal cord and, further, suggest that these nucleotides are involved in the modulation of hyperalgesia in the spinal cord.

Original language	English (US)
Pages (from-to)	135-139
Number of pages	5
Journal	Brain Research
Volume	646
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(94)90066-3
State	Published - May 16 1994
Externally published	Yes

Keywords

Carrageenan Inflammation
Dorsal horn
Hyperalgesia
Immunoreactive cAMP
Immunoreactive cGMP

ASJC Scopus subject areas

Clinical Neurology
Molecular Biology
General Neuroscience
Developmental Biology

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10.1016/0006-8993(94)90066-3

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title = "Carrageenan-induced inflammation alters the content of i-cGMP and i-cAMP in the dorsal horn of the spinal cord",

abstract = "Hindpaw injections of carrageenan (CARRA) decreased paw withdrawal latencies to radiant heat and increased hindpaw edema. At the peak of hyperalgesia, the content of immunoreactive guanosine 3′,5′-cyclic monophosphate (i-cGMP) was increased, while immunoreactive adenosine 3′,5′-cyclic monophosphate (i-cAMP) was decreased in lumbar, but not cervical dorsal horn. In general, the content of i-cGMP in the dorsal horn was correlated with thermal hyperalgesia throughout the course of this model. These results indicate that a peripheral inflammation alters the content of i-cGMP and i-cAMP in the spinal cord and, further, suggest that these nucleotides are involved in the modulation of hyperalgesia in the spinal cord.",

keywords = "Carrageenan Inflammation, Dorsal horn, Hyperalgesia, Immunoreactive cAMP, Immunoreactive cGMP",

author = "Garry, {Mary G.} and Richardson, {Jennelle Durnett} and Hargreaves, {Kenneth M.}",

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T1 - Carrageenan-induced inflammation alters the content of i-cGMP and i-cAMP in the dorsal horn of the spinal cord

AU - Garry, Mary G.

AU - Richardson, Jennelle Durnett

AU - Hargreaves, Kenneth M.

PY - 1994/5/16

Y1 - 1994/5/16

N2 - Hindpaw injections of carrageenan (CARRA) decreased paw withdrawal latencies to radiant heat and increased hindpaw edema. At the peak of hyperalgesia, the content of immunoreactive guanosine 3′,5′-cyclic monophosphate (i-cGMP) was increased, while immunoreactive adenosine 3′,5′-cyclic monophosphate (i-cAMP) was decreased in lumbar, but not cervical dorsal horn. In general, the content of i-cGMP in the dorsal horn was correlated with thermal hyperalgesia throughout the course of this model. These results indicate that a peripheral inflammation alters the content of i-cGMP and i-cAMP in the spinal cord and, further, suggest that these nucleotides are involved in the modulation of hyperalgesia in the spinal cord.

AB - Hindpaw injections of carrageenan (CARRA) decreased paw withdrawal latencies to radiant heat and increased hindpaw edema. At the peak of hyperalgesia, the content of immunoreactive guanosine 3′,5′-cyclic monophosphate (i-cGMP) was increased, while immunoreactive adenosine 3′,5′-cyclic monophosphate (i-cAMP) was decreased in lumbar, but not cervical dorsal horn. In general, the content of i-cGMP in the dorsal horn was correlated with thermal hyperalgesia throughout the course of this model. These results indicate that a peripheral inflammation alters the content of i-cGMP and i-cAMP in the spinal cord and, further, suggest that these nucleotides are involved in the modulation of hyperalgesia in the spinal cord.

KW - Carrageenan Inflammation

KW - Dorsal horn

KW - Hyperalgesia

KW - Immunoreactive cAMP

KW - Immunoreactive cGMP

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Carrageenan-induced inflammation alters the content of i-cGMP and i-cAMP in the dorsal horn of the spinal cord

Abstract

Keywords

ASJC Scopus subject areas

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