Carrageenan-induced inflammation alters the content of i-cGMP and i-cAMP in the dorsal horn of the spinal cord

Mary G. Garry, Jennelle Durnett Richardson, Kenneth M. Hargreaves

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Hindpaw injections of carrageenan (CARRA) decreased paw withdrawal latencies to radiant heat and increased hindpaw edema. At the peak of hyperalgesia, the content of immunoreactive guanosine 3′,5′-cyclic monophosphate (i-cGMP) was increased, while immunoreactive adenosine 3′,5′-cyclic monophosphate (i-cAMP) was decreased in lumbar, but not cervical dorsal horn. In general, the content of i-cGMP in the dorsal horn was correlated with thermal hyperalgesia throughout the course of this model. These results indicate that a peripheral inflammation alters the content of i-cGMP and i-cAMP in the spinal cord and, further, suggest that these nucleotides are involved in the modulation of hyperalgesia in the spinal cord.

Original languageEnglish (US)
Pages (from-to)135-139
Number of pages5
JournalBrain Research
Volume646
Issue number1
DOIs
StatePublished - May 16 1994
Externally publishedYes

Keywords

  • Carrageenan Inflammation
  • Dorsal horn
  • Hyperalgesia
  • Immunoreactive cAMP
  • Immunoreactive cGMP

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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