Cariogenic biofilms: Development, properties, and biomimetic preventive agents

Frederic Meyer, Joachim Enax, Matthias Epple, Bennett T. Amaechi, Barbara Simader

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Oral biofilms will build up within minutes after cleaning of the dental hard tissues. While the application of remineralizing agents is a well-known approach to prevent dental caries, modern oral care products offer also additional active agents to maintain oral health. Human saliva contains many different organic and inorganic compounds that help to buffer organic acids produced by cariogenic microorganisms. However, most oral care products only contain remineralizing agents. To improve the benefit of those products, further active ingredients are needed. Books, review articles, and original research papers were included in this narrative review. Putting all these data together, we give an overview of oral biofilms and active compounds used in modern oral care products to interact with them. The special focus is on inorganic compounds and their interaction with oral biofilms. While organic compounds have several limitations (e.g., cell toxicity), inorganic compounds based on calcium and/or phosphate (e.g., sodium bicarbonate, hydroxyapatite, calcium carbonate) offer several advantages when used in oral care products. Calcium release can inhibit demineralization, and the release of hydroxide and phosphate ions might help in the buffering of acids. Therefore, the focus of this review is to summarize the scientific background of further active ingredients that can be used for oral care formulations.

Original languageEnglish (US)
Article number88
JournalDentistry Journal
Issue number8
StatePublished - Aug 2021


  • Amino acids
  • Calcium carbonate
  • Calcium phosphates
  • Hydroxyapatite
  • PH value

ASJC Scopus subject areas

  • General Dentistry


Dive into the research topics of 'Cariogenic biofilms: Development, properties, and biomimetic preventive agents'. Together they form a unique fingerprint.

Cite this