Care of patients with burns and traumatic brain injury

Leopoldo C. Cancio, Basil A Pruitt

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


The combination of thermal injury and traumatic brain injury (TBI) poses a significant resuscitation challenge. Limited data exist on the effect of severe burns (>20 % of the total body surface area) on the brain. These data suggest that even in the absence of TBI, burns may cause disruption of the blood-brain barrier (BBB). Burn patients require large volumes (2-4 ml/kg/% burn) of fluid for resuscitation during the first 24 h postburn. This, combined with loss of BBB integrity, may cause cerebral edema during the early postburn period. In patients with TBI and burns, close attention to parsimonious fluid management; liberal use of intracranial pressure monitoring during resuscitation; and careful consideration of alternative approaches to include hypertonic saline or mannitol infusion may be required.

Original languageEnglish (US)
Title of host publicationNeurotrauma Management for the Severely Injured Polytrauma Patient
PublisherSpringer International Publishing
Number of pages8
ISBN (Electronic)9783319402086
ISBN (Print)9783319402062
StatePublished - Jan 1 2017


  • Aeromedical evacuation
  • Blood-brain barrier
  • Burns
  • Cerebral edema
  • Cytokines
  • Delirium
  • Fluid resuscitation
  • Inhalation injury
  • Intracranial pressure
  • Posttraumatic stress disorder
  • Traumatic brain injury

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Care of patients with burns and traumatic brain injury'. Together they form a unique fingerprint.

Cite this