Cardiovascular risk factors in non-insulin-dependent diabetic subjects with microalbuminuria

Steven M. Haffner, Philip A. Morales, M. Katherine Gruber, Helen P. Hazuda, Michael P. Stern

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

In subjects with insulin-dependent diabetes mellitus, microalbuminuria has been associated with increased triglyceride and lipoprotein (a) (Lp[a]) concentrations and increased blood pressure. However, few studies have examined whether this association is present in subjects with non-insulin-dependent diabetes mellitus (NIDDM). We measured lipids, lipoproteins, Lp(a), blood pressure, and albumin excretion in 234 subjects with NIDDM from the San Antonio Heart Study, a population-based study of diabetes and cardiovascular disease. Seventy-two subjects had microalbuminuria (≥30 mg/dl). These subjects had increased systolic and diastolic blood pressures and higher fasting glucose concentrations relative to subjects without microalbuminuria. However, there were no significant differences between subjects with and without microalbuminuria with respect to lipids, lipoproteins, Lp(a), self-reported myocardial infarction, obesity, or body fat distribution. Subjects with diabetic retinopathy had increased microalbuminuria. In multivariate analysis both glycemia and blood pressure continued to be significantly related to the presence of microalbuminuria. We conclude that NIDDM subjects with microalbuminuria have elevated blood pressure and more severe glycemia but do not have a significantly more atherogenic pattern of lipids, lipoproteins, or Lp(a) than subjects without microalbuminuria.

Original languageEnglish (US)
Pages (from-to)205-210
Number of pages6
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume13
Issue number2
DOIs
StatePublished - 1993

Keywords

  • Blood pressure
  • Lipids
  • Lipoprotein (a)
  • Lipoproteins
  • Microalbuminuria
  • Non-insulin-dependent diabetes mellitus

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Cardiovascular risk factors in non-insulin-dependent diabetic subjects with microalbuminuria'. Together they form a unique fingerprint.

Cite this