Abstract
Meta-analyses of clinical trials suggest that the use of the thiazolidinedione (TZD), rosiglitazone, in patients with type 2 diabetes mellitus may increase the risk of myocardial ischaemic events by 30-40%. Although these controversial data must be interpreted with caution, in the absence of definitive prospective cardiovascular (CV) outcomes data, they represent a prominent source of evidence concerning the CV safety of rosiglitazone. The results of meta-analyses and a large randomized-controlled CV outcomes trial provide strong evidence that pioglitazone does not increase the risk of coronary events. This article clarifies the clinical significance of these meta-analytical findings alongside other sources of evidence and assesses their impact on evolving treatment guidelines and recommendations for the use of TZDs in patients with type 2 diabetes.
Original language | English (US) |
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Pages (from-to) | 1023-1035 |
Number of pages | 13 |
Journal | Diabetes, Obesity and Metabolism |
Volume | 12 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2010 |
Keywords
- Cardiovascular disease
- Myocardial infarction
- Pioglitazone
- Rosiglitazone
- Thiazolidinediones
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Endocrinology