Cardiovascular diseases: Protective effects of melatonin

Sandra Tengattini, Russel J. Reiter, Dun Xian Tan, M. Pilar Terron, Luigi F. Rodella, Rita Rezzani

Research output: Contribution to journalShort surveypeer-review

249 Scopus citations

Abstract

This brief review considers some of the cardiac diseases and conditions where free radicals and related reactants are believed to be causative. The report also describes the beneficial actions of melatonin against oxidative cardiovascular disorders. Based on the data available, melatonin seems to have cardioprotective properties via its direct free radical scavenger and its indirect antioxidant activity. Melatonin efficiently interacts with various reactive oxygen and reactive nitrogen species (receptor independent actions) and it also upregulates antioxidant enzymes and downregulates pro-oxidant enzymes (receptor-dependent actions). Moreover, melatonin enters all cells and subcellular compartments and crosses morphophysiologic barriers. These findings have implications for the protective effects of melatonin against cardiac diseases induced by oxidative stress. Melatonin attenuates molecular and cellular damages resulting from cardiac ischemia/reperfusion in which destructive free radicals are involved. Anti-inflammatory and antioxidative properties of melatonin are also involved in the protection against a chronic vascular disease, atherosclerosis. The administration of melatonin, as a result of its antioxidant features, has been reported to reduce hypertension and cardiotoxicity induced by clinically used drugs. The results described herein help to clarify the beneficial effects of melatonin against these conditions and define the potential clinical applicability of melatonin in cardiovascular diseases.

Original languageEnglish (US)
Pages (from-to)16-25
Number of pages10
JournalJournal of pineal research
Volume44
Issue number1
DOIs
StatePublished - Jan 1 2008

Keywords

  • Antioxidant
  • Atherosclerosis
  • Cardiac pathophysiology
  • Hypertension
  • Ischemia/reperfusion
  • Melatonin
  • Oxidative damage

ASJC Scopus subject areas

  • Endocrinology

Fingerprint Dive into the research topics of 'Cardiovascular diseases: Protective effects of melatonin'. Together they form a unique fingerprint.

Cite this