Cardiovascular disease prevalence and its relation to risk factors in Alaska Eskimos

Barbara V. Howard, Anthony Comuzzie, Richard B. Devereux, Sven O.E. Ebbesson, Richard R. Fabsitz, Wm James Howard, Sandra Laston, Jean W. MacCluer, Angela Silverman, Jason G. Umans, Hong Wang, Neil J. Weissman, Charlotte R. Wenger

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Background and aims: Although Eskimos were thought to be protected from cardiovascular disease (CVD), state health data show a large proportion of deaths from CVD, despite traditional lifestyles and high omega-3 fatty acid intake. This article explores CVD prevalence and its relation to risk factors in Alaska Eskimos. Methods and results: A population-based cohort of 499 Alaska Eskimos > age 45 from the Norton Sound region was examined in 2000-2004 for CVD and associated risk factors as part of the Genetics of Coronary Artery Disease in Alaska Natives study. CVD and atherosclerosis were evaluated and adjudicated using standardized methods. Average age was 58 years; diabetes prevalence was low and high-density lipoprotein cholesterol (HDL-C) concentrations were high, but a large proportion smoked and had high pathogen burden. CVD was higher in men (12.6%) than in women (5.3%) (prevalence ratio 2.4, CI 1.3-4.4). Rates of stroke (6.1% in men, 1.8% in women) were similar to those for coronary heart disease (CHD) (6.1% men, 2.5% women). MI prevalence was low in both genders (1.9% and 0.7%). CVD was higher in men and in those >60 years. Hypertension, diabetes, high LDL-C, high apoB, and low HDL-C were all strong correlates (<.002) and albuminuria and CRP were also correlated with CVD (p<. .05) after adjustment for age and gender. Carotid atherosclerosis was correlated with CVD (p=.0079) independent of other risk factors. Conclusion: These data show high CHD and stroke prevalence in Alaska Eskimos, despite low average LDL-C and high HDL-C. Hypertension and high LDL-C were independent correlates; identifying these risk factors early and treating to target is recommended.

Original languageEnglish (US)
Pages (from-to)350-358
Number of pages9
JournalNutrition, Metabolism and Cardiovascular Diseases
Issue number5
StatePublished - Jun 2010
Externally publishedYes


  • Cardiovascular disease
  • Epidemiology
  • Omega-3 fatty acid
  • Risk factors

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine


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