Cardiovascular disease: much more aggressive in patients with type 2 diabetes.

Elaine Chiquette, Robert Chilton

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


It is estimated that 80% of individuals with type 2 diabetes die of coronary heart disease. Several factors have been found to contribute to the accelerated atherosclerosis present in diabetic patients. These include hyperglycemia-induced endothelial cell dysfunction, impaired fibrinolysis, increased platelet aggregation, and dysfunctional arterial remodeling. The evidence supports that a healthy lifestyle, statin drugs, angiotensin-converting enzyme inhibitors, and aspirin can modify these factors and slow the atherosclerosis process observed in type 2 diabetes. Because of the high prevalence of cardiovascular disease in people with type 2 diabetes, early cardiac testing is indicated. The optimal strategy for coronary revascularization in diabetic patients remains controversial and is discussed in detail in this review.

Original languageEnglish (US)
Pages (from-to)134-142
Number of pages9
JournalCurrent atherosclerosis reports
Issue number2
StatePublished - Mar 2002

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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