TY - JOUR
T1 - Cardiovascular disease
T2 - much more aggressive in patients with type 2 diabetes.
AU - Chiquette, Elaine
AU - Chilton, Robert
PY - 2002/3
Y1 - 2002/3
N2 - It is estimated that 80% of individuals with type 2 diabetes die of coronary heart disease. Several factors have been found to contribute to the accelerated atherosclerosis present in diabetic patients. These include hyperglycemia-induced endothelial cell dysfunction, impaired fibrinolysis, increased platelet aggregation, and dysfunctional arterial remodeling. The evidence supports that a healthy lifestyle, statin drugs, angiotensin-converting enzyme inhibitors, and aspirin can modify these factors and slow the atherosclerosis process observed in type 2 diabetes. Because of the high prevalence of cardiovascular disease in people with type 2 diabetes, early cardiac testing is indicated. The optimal strategy for coronary revascularization in diabetic patients remains controversial and is discussed in detail in this review.
AB - It is estimated that 80% of individuals with type 2 diabetes die of coronary heart disease. Several factors have been found to contribute to the accelerated atherosclerosis present in diabetic patients. These include hyperglycemia-induced endothelial cell dysfunction, impaired fibrinolysis, increased platelet aggregation, and dysfunctional arterial remodeling. The evidence supports that a healthy lifestyle, statin drugs, angiotensin-converting enzyme inhibitors, and aspirin can modify these factors and slow the atherosclerosis process observed in type 2 diabetes. Because of the high prevalence of cardiovascular disease in people with type 2 diabetes, early cardiac testing is indicated. The optimal strategy for coronary revascularization in diabetic patients remains controversial and is discussed in detail in this review.
UR - http://www.scopus.com/inward/record.url?scp=0038114530&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038114530&partnerID=8YFLogxK
U2 - 10.1007/s11883-002-0037-z
DO - 10.1007/s11883-002-0037-z
M3 - Review article
C2 - 11822977
AN - SCOPUS:0038114530
SN - 1523-3804
VL - 4
SP - 134
EP - 142
JO - Current atherosclerosis reports
JF - Current atherosclerosis reports
IS - 2
ER -