Cardiovascular and neuroendocrine responses to behavioral stress after central or peripheral barodenervation in rats

R. Allan Buchholz, John W. Hubbard, T. Kent Keeton, Marc A. Nathan

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The cardiovascular and neuroendocrine responses to acute behavioral stress were evaluated in rats after disruption of the baro reflexes by electrolytic lesions of the nucleus tractus solitarii (NTS) or sinoaortic denervation (SAD). Rats with NTS lesions or SAD showed significantly greater increases in mean arterial pressure (MAP) and plasma norepinephrine (NE) concentrations than control rats during a single 30-min escape-avoidance test. In addition, the increases in MAP and plasma NE concentration of NTS lesion rats were significantly greater than those of SAD rats. However, NTS lesion raats showed no increase in plasma renin activity (PRA), as observed in the other groups. Thus, disruption of the baroreflexes by NTS lesions oraugments the arterial pressure and plasma NE responses to stress. Additionally, NTS lesions appeared to eliminate the neurons or fibers of passage participating in the sympathetically mediated increase in PRA.

Original languageEnglish (US)
Pages (from-to)360-364
Number of pages5
JournalBrain Research
Volume365
Issue number2
DOIs
StatePublished - Feb 19 1986
Externally publishedYes

Keywords

  • baroreflex
  • blood pressure
  • nucleus tractus solitarii
  • plasma catecholamine
  • plasma renin activity
  • sinoaortic denervation
  • stress

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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