SGLT2的心肾保护作用:来自心血管结局试验的经验教训

Translated title of the contribution: Cardiorenal protection with SGLT2: Lessons from the cardiovascular outcome trials

José Silva-Cardoso, Omar Sheikh, Mouhamed Nashawi, Son Pham, Kelly M. Gallegos, Laith R. Dinkha, Robert J. Chilton

Research output: Contribution to journalReview articlepeer-review

Abstract

Sodium glucose cotransporter 2 (SGLT2) inhibitors are a class of drugs that were primarily developed for the treatment of type 2 diabetes mellitus. However, these agents have shown to provide additional beneficial effects. We will discuss three main topics regarding the use of SGLT2 inhibitors: noncardiovascular effects, cardiovascular benefits, and novel clinical indications. Multiple clinical trials and preliminary studies across varying disciplines have shown that these agents exhibit cardiorenal-protective benefits, retinoprotective benefits, and may aid in weight loss without causing marked hypoglycemia. Therefore, these agents represent an avenue in clinical practice to manage comorbid conditions in the hyperglycemic patient. Because of their multifaceted effects and robust action, SGLT2 inhibitors represent therapy options for providers that not only provide beneficial clinical results but also reduce total patient drug burden.

Translated title of the contributionCardiorenal protection with SGLT2: Lessons from the cardiovascular outcome trials
Original languageChinese
Pages (from-to)279-293
Number of pages15
JournalJournal of Diabetes
Volume12
Issue number4
DOIs
StatePublished - Apr 1 2020

Keywords

  • diabetic nephropathy
  • heart failure
  • macrovascular
  • microvascular
  • retinopathy
  • SGLT2 inhibitors
  • translational biology

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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