Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

Elahu G. Sustarsic; Tao Ma; Matthew D. Lynes; Michael Larsen; Iuliia Karavaeva; Jesper F. Havelund; Carsten H. Nielsen; Mark P. Jedrychowski; Marta Moreno-Torres; Morten Lundh; Kaja Plucinska; Naja Z. Jespersen; Trisha J. Grevengoed; Barbara Kramar; Julia Peics; Jakob B. Hansen; Farnaz Shamsi; Isabel Forss; Ditte Neess; Susanne Keipert; Jianing Wang; Katharina Stohlmann; Ivan Brandslund; Cramer Christensen; Marit E. Jørgensen; Allan Linneberg; Oluf Pedersen; Michael A. Kiebish; Klaus Qvortrup; Xianlin Han; Bente Klarlund Pedersen; Martin Jastroch; Susanne Mandrup; Andreas Kjær; Steven P. Gygi; Torben Hansen; Matthew P. Gillum; Niels Grarup; Brice Emanuelli; Søren Nielsen; Camilla Scheele; Yu Hua Tseng; Nils J. Færgeman; Zachary Gerhart-Hines

doi:10.1016/j.cmet.2018.05.003

Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

Elahu G. Sustarsic
, Tao Ma
, Matthew D. Lynes
, Michael Larsen
, Iuliia Karavaeva
, Jesper F. Havelund
, Carsten H. Nielsen
, Mark P. Jedrychowski
, Marta Moreno-Torres
, Morten Lundh
, Kaja Plucinska
, Naja Z. Jespersen
, Trisha J. Grevengoed
, Barbara Kramar
, Julia Peics
, Jakob B. Hansen
, Farnaz Shamsi
, Isabel Forss
, Ditte Neess
, Susanne Keipert

Jianing Wang, Katharina Stohlmann, Ivan Brandslund, Cramer Christensen, Marit E. Jørgensen, Allan Linneberg, Oluf Pedersen, Michael A. Kiebish, Klaus Qvortrup, Xianlin Han, Bente Klarlund Pedersen, Martin Jastroch, Susanne Mandrup, Andreas Kjær, Steven P. Gygi, Torben Hansen, Matthew P. Gillum, Niels Grarup, Brice Emanuelli, Søren Nielsen, Camilla Scheele, Yu Hua Tseng, Nils J. Færgeman, Zachary Gerhart-Hines

Research output: Contribution to journal › Article › peer-review

142 Scopus citations

Abstract

Sustarsic et al. reveal that synthesis of the mitochondrial phospholipid cardiolipin is a hallmark of brown and beige fat activation by cold temperature. This single lipid species in thermogenic fat not only shapes adipose mitochondrial bioenergetics but also exerts profound control over whole-body insulin sensitivity and metabolic flexibility.

Original language	English (US)
Pages (from-to)	159-174.e11
Journal	Cell Metabolism
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2018.05.003
State	Published - Jul 3 2018

Keywords

CHOP-10
CRLS1
beige adipose
brown adipose
cardiolipin
insulin resistance
lipid metabolism
mitochondria
phospholipids
thermogenesis

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

Access to Document

10.1016/j.cmet.2018.05.003

Cite this

Sustarsic, E. G., Ma, T., Lynes, M. D., Larsen, M., Karavaeva, I., Havelund, J. F., Nielsen, C. H., Jedrychowski, M. P., Moreno-Torres, M., Lundh, M., Plucinska, K., Jespersen, N. Z., Grevengoed, T. J., Kramar, B., Peics, J., Hansen, J. B., Shamsi, F., Forss, I., Neess, D., ... Gerhart-Hines, Z. (2018). Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis. Cell Metabolism, 28(1), 159-174.e11. https://doi.org/10.1016/j.cmet.2018.05.003

Sustarsic, EG, Ma, T, Lynes, MD, Larsen, M, Karavaeva, I, Havelund, JF, Nielsen, CH, Jedrychowski, MP, Moreno-Torres, M, Lundh, M, Plucinska, K, Jespersen, NZ, Grevengoed, TJ, Kramar, B, Peics, J, Hansen, JB, Shamsi, F, Forss, I, Neess, D, Keipert, S, Wang, J, Stohlmann, K, Brandslund, I, Christensen, C, Jørgensen, ME, Linneberg, A, Pedersen, O, Kiebish, MA, Qvortrup, K, Han, X, Pedersen, BK, Jastroch, M, Mandrup, S, Kjær, A, Gygi, SP, Hansen, T, Gillum, MP, Grarup, N, Emanuelli, B, Nielsen, S, Scheele, C, Tseng, YH, Færgeman, NJ & Gerhart-Hines, Z 2018, 'Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis', Cell Metabolism, vol. 28, no. 1, pp. 159-174.e11. https://doi.org/10.1016/j.cmet.2018.05.003

@article{8292f6881308447ca02e8abe7c9b33d0,

title = "Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis",

abstract = "Sustarsic et al. reveal that synthesis of the mitochondrial phospholipid cardiolipin is a hallmark of brown and beige fat activation by cold temperature. This single lipid species in thermogenic fat not only shapes adipose mitochondrial bioenergetics but also exerts profound control over whole-body insulin sensitivity and metabolic flexibility.",

keywords = "CHOP-10, CRLS1, beige adipose, brown adipose, cardiolipin, insulin resistance, lipid metabolism, mitochondria, phospholipids, thermogenesis",

author = "Sustarsic, \{Elahu G.\} and Tao Ma and Lynes, \{Matthew D.\} and Michael Larsen and Iuliia Karavaeva and Havelund, \{Jesper F.\} and Nielsen, \{Carsten H.\} and Jedrychowski, \{Mark P.\} and Marta Moreno-Torres and Morten Lundh and Kaja Plucinska and Jespersen, \{Naja Z.\} and Grevengoed, \{Trisha J.\} and Barbara Kramar and Julia Peics and Hansen, \{Jakob B.\} and Farnaz Shamsi and Isabel Forss and Ditte Neess and Susanne Keipert and Jianing Wang and Katharina Stohlmann and Ivan Brandslund and Cramer Christensen and J{\o}rgensen, \{Marit E.\} and Allan Linneberg and Oluf Pedersen and Kiebish, \{Michael A.\} and Klaus Qvortrup and Xianlin Han and Pedersen, \{Bente Klarlund\} and Martin Jastroch and Susanne Mandrup and Andreas Kj{\ae}r and Gygi, \{Steven P.\} and Torben Hansen and Gillum, \{Matthew P.\} and Niels Grarup and Brice Emanuelli and S{\o}ren Nielsen and Camilla Scheele and Tseng, \{Yu Hua\} and F{\ae}rgeman, \{Nils J.\} and Zachary Gerhart-Hines",

year = "2018",

month = jul,

day = "3",

doi = "10.1016/j.cmet.2018.05.003",

language = "English (US)",

volume = "28",

pages = "159--174.e11",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "1",

}

TY - JOUR

T1 - Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

AU - Sustarsic, Elahu G.

AU - Ma, Tao

AU - Lynes, Matthew D.

AU - Larsen, Michael

AU - Karavaeva, Iuliia

AU - Havelund, Jesper F.

AU - Nielsen, Carsten H.

AU - Jedrychowski, Mark P.

AU - Moreno-Torres, Marta

AU - Lundh, Morten

AU - Plucinska, Kaja

AU - Jespersen, Naja Z.

AU - Grevengoed, Trisha J.

AU - Kramar, Barbara

AU - Peics, Julia

AU - Hansen, Jakob B.

AU - Shamsi, Farnaz

AU - Forss, Isabel

AU - Neess, Ditte

AU - Keipert, Susanne

AU - Wang, Jianing

AU - Stohlmann, Katharina

AU - Brandslund, Ivan

AU - Christensen, Cramer

AU - Jørgensen, Marit E.

AU - Linneberg, Allan

AU - Pedersen, Oluf

AU - Kiebish, Michael A.

AU - Qvortrup, Klaus

AU - Han, Xianlin

AU - Pedersen, Bente Klarlund

AU - Jastroch, Martin

AU - Mandrup, Susanne

AU - Kjær, Andreas

AU - Gygi, Steven P.

AU - Hansen, Torben

AU - Gillum, Matthew P.

AU - Grarup, Niels

AU - Emanuelli, Brice

AU - Nielsen, Søren

AU - Scheele, Camilla

AU - Tseng, Yu Hua

AU - Færgeman, Nils J.

AU - Gerhart-Hines, Zachary

PY - 2018/7/3

Y1 - 2018/7/3

N2 - Sustarsic et al. reveal that synthesis of the mitochondrial phospholipid cardiolipin is a hallmark of brown and beige fat activation by cold temperature. This single lipid species in thermogenic fat not only shapes adipose mitochondrial bioenergetics but also exerts profound control over whole-body insulin sensitivity and metabolic flexibility.

AB - Sustarsic et al. reveal that synthesis of the mitochondrial phospholipid cardiolipin is a hallmark of brown and beige fat activation by cold temperature. This single lipid species in thermogenic fat not only shapes adipose mitochondrial bioenergetics but also exerts profound control over whole-body insulin sensitivity and metabolic flexibility.

KW - CHOP-10

KW - CRLS1

KW - beige adipose

KW - brown adipose

KW - cardiolipin

KW - insulin resistance

KW - lipid metabolism

KW - mitochondria

KW - phospholipids

KW - thermogenesis

UR - https://www.scopus.com/pages/publications/85047218679

UR - https://www.scopus.com/pages/publications/85047218679#tab=citedBy

U2 - 10.1016/j.cmet.2018.05.003

DO - 10.1016/j.cmet.2018.05.003

M3 - Article

C2 - 29861389

AN - SCOPUS:85047218679

SN - 1550-4131

VL - 28

SP - 159-174.e11

JO - Cell Metabolism

JF - Cell Metabolism

IS - 1

ER -

Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this