Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

Elahu G. Sustarsic, Tao Ma, Matthew D. Lynes, Michael Larsen, Iuliia Karavaeva, Jesper F. Havelund, Carsten H. Nielsen, Mark P. Jedrychowski, Marta Moreno-Torres, Morten Lundh, Kaja Plucinska, Naja Z. Jespersen, Trisha J. Grevengoed, Barbara Kramar, Julia Peics, Jakob B. Hansen, Farnaz Shamsi, Isabel Forss, Ditte Neess, Susanne Keipert & 24 others Jianing Wang, Katharina Stohlmann, Ivan Brandslund, Cramer Christensen, Marit E. Jørgensen, Allan Linneberg, Oluf Pedersen, Michael A. Kiebish, Klaus Qvortrup, Xianlin Han, Bente Klarlund Pedersen, Martin Jastroch, Susanne Mandrup, Andreas Kjær, Steven P. Gygi, Torben Hansen, Matthew P. Gillum, Niels Grarup, Brice Emanuelli, Søren Nielsen, Camilla Scheele, Yu Hua Tseng, Nils J. Færgeman, Zachary Gerhart-Hines

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Sustarsic et al. reveal that synthesis of the mitochondrial phospholipid cardiolipin is a hallmark of brown and beige fat activation by cold temperature. This single lipid species in thermogenic fat not only shapes adipose mitochondrial bioenergetics but also exerts profound control over whole-body insulin sensitivity and metabolic flexibility.

Original languageEnglish (US)
Pages (from-to)159-174.e11
JournalCell Metabolism
Volume28
Issue number1
DOIs
StatePublished - Jul 3 2018

Fingerprint

Cardiolipins
Brown Adipose Tissue
Energy Metabolism
Insulin Resistance
Phospholipids
Mitochondria
Homeostasis
Fats
Lipids
Beige Adipose Tissue

Keywords

  • beige adipose
  • brown adipose
  • cardiolipin
  • CHOP-10
  • CRLS1
  • insulin resistance
  • lipid metabolism
  • mitochondria
  • phospholipids
  • thermogenesis

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

Cite this

Sustarsic, E. G., Ma, T., Lynes, M. D., Larsen, M., Karavaeva, I., Havelund, J. F., ... Gerhart-Hines, Z. (2018). Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis. Cell Metabolism, 28(1), 159-174.e11. https://doi.org/10.1016/j.cmet.2018.05.003

Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis. / Sustarsic, Elahu G.; Ma, Tao; Lynes, Matthew D.; Larsen, Michael; Karavaeva, Iuliia; Havelund, Jesper F.; Nielsen, Carsten H.; Jedrychowski, Mark P.; Moreno-Torres, Marta; Lundh, Morten; Plucinska, Kaja; Jespersen, Naja Z.; Grevengoed, Trisha J.; Kramar, Barbara; Peics, Julia; Hansen, Jakob B.; Shamsi, Farnaz; Forss, Isabel; Neess, Ditte; Keipert, Susanne; Wang, Jianing; Stohlmann, Katharina; Brandslund, Ivan; Christensen, Cramer; Jørgensen, Marit E.; Linneberg, Allan; Pedersen, Oluf; Kiebish, Michael A.; Qvortrup, Klaus; Han, Xianlin; Pedersen, Bente Klarlund; Jastroch, Martin; Mandrup, Susanne; Kjær, Andreas; Gygi, Steven P.; Hansen, Torben; Gillum, Matthew P.; Grarup, Niels; Emanuelli, Brice; Nielsen, Søren; Scheele, Camilla; Tseng, Yu Hua; Færgeman, Nils J.; Gerhart-Hines, Zachary.

In: Cell Metabolism, Vol. 28, No. 1, 03.07.2018, p. 159-174.e11.

Research output: Contribution to journalArticle

Sustarsic, EG, Ma, T, Lynes, MD, Larsen, M, Karavaeva, I, Havelund, JF, Nielsen, CH, Jedrychowski, MP, Moreno-Torres, M, Lundh, M, Plucinska, K, Jespersen, NZ, Grevengoed, TJ, Kramar, B, Peics, J, Hansen, JB, Shamsi, F, Forss, I, Neess, D, Keipert, S, Wang, J, Stohlmann, K, Brandslund, I, Christensen, C, Jørgensen, ME, Linneberg, A, Pedersen, O, Kiebish, MA, Qvortrup, K, Han, X, Pedersen, BK, Jastroch, M, Mandrup, S, Kjær, A, Gygi, SP, Hansen, T, Gillum, MP, Grarup, N, Emanuelli, B, Nielsen, S, Scheele, C, Tseng, YH, Færgeman, NJ & Gerhart-Hines, Z 2018, 'Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis', Cell Metabolism, vol. 28, no. 1, pp. 159-174.e11. https://doi.org/10.1016/j.cmet.2018.05.003
Sustarsic EG, Ma T, Lynes MD, Larsen M, Karavaeva I, Havelund JF et al. Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis. Cell Metabolism. 2018 Jul 3;28(1):159-174.e11. https://doi.org/10.1016/j.cmet.2018.05.003
Sustarsic, Elahu G. ; Ma, Tao ; Lynes, Matthew D. ; Larsen, Michael ; Karavaeva, Iuliia ; Havelund, Jesper F. ; Nielsen, Carsten H. ; Jedrychowski, Mark P. ; Moreno-Torres, Marta ; Lundh, Morten ; Plucinska, Kaja ; Jespersen, Naja Z. ; Grevengoed, Trisha J. ; Kramar, Barbara ; Peics, Julia ; Hansen, Jakob B. ; Shamsi, Farnaz ; Forss, Isabel ; Neess, Ditte ; Keipert, Susanne ; Wang, Jianing ; Stohlmann, Katharina ; Brandslund, Ivan ; Christensen, Cramer ; Jørgensen, Marit E. ; Linneberg, Allan ; Pedersen, Oluf ; Kiebish, Michael A. ; Qvortrup, Klaus ; Han, Xianlin ; Pedersen, Bente Klarlund ; Jastroch, Martin ; Mandrup, Susanne ; Kjær, Andreas ; Gygi, Steven P. ; Hansen, Torben ; Gillum, Matthew P. ; Grarup, Niels ; Emanuelli, Brice ; Nielsen, Søren ; Scheele, Camilla ; Tseng, Yu Hua ; Færgeman, Nils J. ; Gerhart-Hines, Zachary. / Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis. In: Cell Metabolism. 2018 ; Vol. 28, No. 1. pp. 159-174.e11.
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