Cardiac Output Determination by Thermodilution Technique: The Method of Choice in Low Flow States (41164)

Barry A. Levine, Kenneth R. Sirinek

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The purpose of this study was to investigate the validity of the thermodilution technique of determining cardiac output in low flow states. We compared the simultaneous determinations attained by the thermodilution method to those made by microsphere dilution and electromagnetic flow transducer methods. Measurements were carried out in five awake miniature swine (10-14 kg) by means of chronically implanted ascending aortic flow transducer and left atrial catheters. A Swan—Ganz thermodilution catheter and a femoral arterial catheter were placed on the morning of the study. Four simultaneous cardiac output determinations were carried out in each animal using the three techniques. The first two measurements were made during normotension and the last two during graded, stable hypovolemic shock (mean arterial pressure, 75 and 50 mm Hg). In addition, 34 simultaneous measurements of cardiac output were carried out using thermodilution and flow transducer methods. No significant difference occurred among the cardiac outputs derived by any of the three methods used, either during normotension or shock. Linear regression analysis showed excellent correlation between thermodilution and each of the other methods. The results of this study show thermodilution to be an accurate, repeatable technique for measurement of cardiac output in low flow states, including shock, thus widening its applicability in experimental models.

Original languageEnglish (US)
Pages (from-to)279-283
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number2
StatePublished - Jun 1981

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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