Cardiac manifestations of congenital generalized lipodystrophy

Vani P. Sanon, Yehuda Handelsman, Son V. Pham, Robert Chilton

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Congenital lipodystrophy is a rare genetic disorder characterized by a near-complete absence of fat cells, hypoleptinemia leading to a voracious appetite, and marked insulin resistance. This article focuses on the known cardiovascular manifestations of patients with congenital lipodystrophy, including cardiomyopathy, cardiac arrhythmias, and accelerated atherosclerosis arising from a markedly deranged metabolic milieu. Future research that targets leptin deficiency (metreleptin) and apoC3 mRNA (antisense oligonucleotide) could open a window for potential pharmacological treatment of this challenging disorder.

Original languageEnglish (US)
Pages (from-to)181-186
Number of pages6
JournalClinical Diabetes
Volume34
Issue number4
DOIs
StatePublished - 2016

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Fingerprint Dive into the research topics of 'Cardiac manifestations of congenital generalized lipodystrophy'. Together they form a unique fingerprint.

  • Cite this