Cardiac magnetic resonance imaging: Insights into developmental programming and its consequences for aging

G. D. Clarke, J. Li, A. H. Kuo, A. J. Moody, P. W. Nathanielsz

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Cardiovascular diseases (CVD) are important consequences of adverse perinatal conditions such as fetal hypoxia and maternal malnutrition. Cardiac magnetic resonance imaging (CMR) can produce a wealth of physiological information related to the development of the heart. This review outlines the current state of CMR technologies and describes the physiological biomarkers that can be measured. These phenotypes include impaired ventricular and atrial function, maladaptive ventricular remodeling, and the proliferation of myocardial steatosis and fibrosis. The discussion outlines the applications of CMR to understanding the developmental pathways leading to impaired cardiac function. The use of CMR, both in animal models of developmental programming and in human studies, is described. Specific examples are given in a baboon model of intrauterine growth restriction (IUGR). CMR offers great potential as a tool for understanding the sequence of dysfunctional adaptations of developmental origin that can affect the human cardiovascular system.

Original languageEnglish (US)
Pages (from-to)203-219
Number of pages17
JournalJournal of developmental origins of health and disease
Volume12
Issue number2
DOIs
StatePublished - Apr 2021
Externally publishedYes

Keywords

  • Heart disease
  • cardiac MRI
  • developmental programming
  • ventricular remodeling

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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