Cardiac hypertrophy and remodelling: Pathophysiological consequences and protective effects of melatonin

Russel J Reiter, Lucien C. Manchester, Lorena Fuentes-Broto, Dun Xian Tan

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

This survey summarizes the limited findings related to the ability of endogenously produced and exogenously administered melatonin to modify the response of the heart musculature to pathological situations that are normally accompanied by hypertrophy of the cardiomyocytes and alterations in cardiovascular physiology. Whereas melatonin did not reduce left ventricular hypertrophy in spontaneously hypertensive rats or in nitric oxide-deficient hypertension, it did have other beneficial effects, e.g. it curtailed oxidative damage to the heart that resulted in an attenuation of left ventricular fibrosis. In contrast to the findings in hypertensive rats, melatonin administration was effective in overcoming cardiac enlargement resulting from induced hyperthyroidism or chronic hypoxia exposure. In addition, in these situations, melatonin also conferred protection against free radical-mediated damage at the level of cardiomyocytes. Collectively, the results of the publications summarized herein along with numerous other published reports on other aspects of cardiovascular physiology indicate that, when damage to the heart is a result of free radicals, melatonin is clearly protective. This is not unexpected considering the now well documented potent antioxidative actions of both melatonin and its metabolites. In general, melatonin improves cardiovascular physiology and heart function.

Original languageEnglish (US)
JournalJournal of Hypertension
Volume28
Issue numberSUPPL. 1
DOIs
StatePublished - Sep 2010

Fingerprint

Cardiomegaly
Melatonin
Cardiovascular Physiological Phenomena
Cardiac Myocytes
Free Radicals
Left Ventricular Hypertrophy
Inbred SHR Rats
Hyperthyroidism
Hypertrophy
Publications
Nitric Oxide
Fibrosis
Hypertension

Keywords

  • +oxidative stress
  • antioxidant
  • cardiac hypertrophy
  • cardiomyocytes
  • heart
  • left ventricle
  • melatonin

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Cardiac hypertrophy and remodelling : Pathophysiological consequences and protective effects of melatonin. / Reiter, Russel J; Manchester, Lucien C.; Fuentes-Broto, Lorena; Tan, Dun Xian.

In: Journal of Hypertension, Vol. 28, No. SUPPL. 1, 09.2010.

Research output: Contribution to journalArticle

Reiter, Russel J ; Manchester, Lucien C. ; Fuentes-Broto, Lorena ; Tan, Dun Xian. / Cardiac hypertrophy and remodelling : Pathophysiological consequences and protective effects of melatonin. In: Journal of Hypertension. 2010 ; Vol. 28, No. SUPPL. 1.
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