Cardiac dysfunction in patients seropositive for the human immunodeficiency virus

J. E. Johnson, D. M. Slife, G. T. Anders, S. R. Bailey, H. M. Blanton, C. K. McAllister, R. D. Latham

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


To confirm the presence of cardiac dysfunction in a group of patients seropositive for the human immunodeficiency virus with either dyspnea on exertion or a reduced anaerobic threshold, 9 patients with no history of opportunistic infection underwent exercise right-sided heart catheterization. When compared with 13 control patients previously exercised in the same manner, the patients showed elevated exercise pulmonary capillary wedge pressure (14.6 ± 3.3 mm of mercury versus 9.9 ± 3.3 mm of mercury; P < .005) and right atrial pressure (10.1 ± 2.1 mm of mercury versus 4.7 ± 3.2 mm of mercury; P < .001) at a similar exercise oxygen consumption and cardiac index. Of the 9 patients, 8 had at least 1 catheterization value outside the 95% confidence limits for the control group and 4 patients had multiple abnormalities. Values for blood CD4 lymphocytes were 0.2 x 109 per liter or more for 7 of the 9. One patient underwent endomyocardial biopsy with findings consistent with a cardiomyopathy. We conclude that cardiac disease may occur at any immunologic stage of human immunodeficiency virus infection. These observations suggest an effect of this disease on the heart.

Original languageEnglish (US)
Pages (from-to)373-379
Number of pages7
JournalWestern Journal of Medicine
Issue number4
StatePublished - 1991

ASJC Scopus subject areas

  • Medicine(all)


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