Abstract
Background: To determine whether continuous veno-venous hemofiltration can ameliorate hemodynamic instability and left ventricular (LV) dysfunction by reducing circulating plasma mediators, the authors used the LV end-systolic elastance (Ees) as a contractility index, in an awake swine model simulating human hyperdynamic endotoxemia. Methods: Nineteen instrumented pigs were divided into a control group (CTRL, n = 7), a hemofiltration (HF, n = 7) group, and an extracorporeal circuit (ECC, n = 5) only group. All animals received intravenous E. coli endotoxin (10 μg • kg • h) and resuscitation in a common regimen for 24 hours. Hemofiltration was started 30 minutes after initiation of endotoxemia and continued until the end of the experiment. Results: Ees was maintained at baseline levels in the HF group, whereas a progressive decrease of Ees was found in both the CTRL and the ECC groups. Cardiac output was significantly higher in the HF group than the CTRL group. There was no significant difference between the groups in plasma catecholamines. Conclusion: We conclude that hemofiltration prevented LV impairment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1055-1061 |
| Number of pages | 7 |
| Journal | Journal of Trauma - Injury, Infection and Critical Care |
| Volume | 67 |
| Issue number | 5 |
| DOIs | |
| State | Published - 2009 |
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Keywords
- Catecholamines
- Endotoxin
- Hemofiltration
- LV function
ASJC Scopus subject areas
- Surgery
- Critical Care and Intensive Care Medicine
Cite this
Cardiac contractility during hemofiltration in an awake model of hyperdynamic endotoxemia. / Ishihara, Satoshi; Ward, John A.; Tasaki, Osamu; Pruitt, Basil A; Mozingo, David W.
In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 67, No. 5, 2009, p. 1055-1061.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cardiac contractility during hemofiltration in an awake model of hyperdynamic endotoxemia
AU - Ishihara, Satoshi
AU - Ward, John A.
AU - Tasaki, Osamu
AU - Pruitt, Basil A
AU - Mozingo, David W.
PY - 2009
Y1 - 2009
N2 - Background: To determine whether continuous veno-venous hemofiltration can ameliorate hemodynamic instability and left ventricular (LV) dysfunction by reducing circulating plasma mediators, the authors used the LV end-systolic elastance (Ees) as a contractility index, in an awake swine model simulating human hyperdynamic endotoxemia. Methods: Nineteen instrumented pigs were divided into a control group (CTRL, n = 7), a hemofiltration (HF, n = 7) group, and an extracorporeal circuit (ECC, n = 5) only group. All animals received intravenous E. coli endotoxin (10 μg • kg • h) and resuscitation in a common regimen for 24 hours. Hemofiltration was started 30 minutes after initiation of endotoxemia and continued until the end of the experiment. Results: Ees was maintained at baseline levels in the HF group, whereas a progressive decrease of Ees was found in both the CTRL and the ECC groups. Cardiac output was significantly higher in the HF group than the CTRL group. There was no significant difference between the groups in plasma catecholamines. Conclusion: We conclude that hemofiltration prevented LV impairment.
AB - Background: To determine whether continuous veno-venous hemofiltration can ameliorate hemodynamic instability and left ventricular (LV) dysfunction by reducing circulating plasma mediators, the authors used the LV end-systolic elastance (Ees) as a contractility index, in an awake swine model simulating human hyperdynamic endotoxemia. Methods: Nineteen instrumented pigs were divided into a control group (CTRL, n = 7), a hemofiltration (HF, n = 7) group, and an extracorporeal circuit (ECC, n = 5) only group. All animals received intravenous E. coli endotoxin (10 μg • kg • h) and resuscitation in a common regimen for 24 hours. Hemofiltration was started 30 minutes after initiation of endotoxemia and continued until the end of the experiment. Results: Ees was maintained at baseline levels in the HF group, whereas a progressive decrease of Ees was found in both the CTRL and the ECC groups. Cardiac output was significantly higher in the HF group than the CTRL group. There was no significant difference between the groups in plasma catecholamines. Conclusion: We conclude that hemofiltration prevented LV impairment.
KW - Catecholamines
KW - Endotoxin
KW - Hemofiltration
KW - LV function
UR - http://www.scopus.com/inward/record.url?scp=73649119918&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=73649119918&partnerID=8YFLogxK
U2 - 10.1097/TA.0b013e3181a5f405
DO - 10.1097/TA.0b013e3181a5f405
M3 - Article
C2 - 19901668
AN - SCOPUS:73649119918
VL - 67
SP - 1055
EP - 1061
JO - Journal of Trauma and Acute Care Surgery
JF - Journal of Trauma and Acute Care Surgery
SN - 2163-0755
IS - 5
ER -