Cardiac contractility during hemofiltration in an awake model of hyperdynamic endotoxemia.

Satoshi Ishihara, John A. Ward, Osamu Tasaki, Basil A. Pruitt, David W. Mozingo

Research output: Contribution to journalArticle

Abstract

BACKGROUND: To determine whether continuous veno-venous hemofiltration can ameliorate hemodynamic instability and left ventricular (LV) dysfunction by reducing circulating plasma mediators, the authors used the LV end-systolic elastance (Ees) as a contractility index, in an awake swine model simulating human hyperdynamic endotoxemia. METHODS: Nineteen instrumented pigs were divided into a control group (CTRL, n = 7), a hemofiltration (HF, n = 7) group, and an extracorporeal circuit (ECC, n = 5) only group. All animals received intravenous E. coli endotoxin (10 microg x kg x h) and resuscitation in a common regimen for 24 hours. Hemofiltration was started 30 minutes after initiation of endotoxemia and continued until the end of the experiment. RESULTS:: Ees was maintained at baseline levels in the HF group, whereas a progressive decrease of Ees was found in both the CTRL and the ECC groups. Cardiac output was significantly higher in the HF group than the CTRL group. There was no significant difference between the groups in plasma catecholamines. CONCLUSION: We conclude that hemofiltration prevented LV impairment.

Original languageEnglish (US)
Pages (from-to)1055-1061
Number of pages7
JournalThe Journal of trauma
Volume67
Issue number5
StatePublished - Nov 2009
Externally publishedYes

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Hemofiltration
Endotoxemia
Swine
Left Ventricular Dysfunction
Endotoxins
Resuscitation
Cardiac Output
Catecholamines
Hemodynamics
Escherichia coli
Control Groups

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ishihara, S., Ward, J. A., Tasaki, O., Pruitt, B. A., & Mozingo, D. W. (2009). Cardiac contractility during hemofiltration in an awake model of hyperdynamic endotoxemia. The Journal of trauma, 67(5), 1055-1061.

Cardiac contractility during hemofiltration in an awake model of hyperdynamic endotoxemia. / Ishihara, Satoshi; Ward, John A.; Tasaki, Osamu; Pruitt, Basil A.; Mozingo, David W.

In: The Journal of trauma, Vol. 67, No. 5, 11.2009, p. 1055-1061.

Research output: Contribution to journalArticle

Ishihara, S, Ward, JA, Tasaki, O, Pruitt, BA & Mozingo, DW 2009, 'Cardiac contractility during hemofiltration in an awake model of hyperdynamic endotoxemia.', The Journal of trauma, vol. 67, no. 5, pp. 1055-1061.
Ishihara S, Ward JA, Tasaki O, Pruitt BA, Mozingo DW. Cardiac contractility during hemofiltration in an awake model of hyperdynamic endotoxemia. The Journal of trauma. 2009 Nov;67(5):1055-1061.
Ishihara, Satoshi ; Ward, John A. ; Tasaki, Osamu ; Pruitt, Basil A. ; Mozingo, David W. / Cardiac contractility during hemofiltration in an awake model of hyperdynamic endotoxemia. In: The Journal of trauma. 2009 ; Vol. 67, No. 5. pp. 1055-1061.
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