TY - JOUR
T1 - Cardiac changes in epileptic baboons with high-frequency microburst VNS therapy
T2 - A pilot study
AU - de la Garza, Melissa A.
AU - Poldiak, D.
AU - Shade, Robert
AU - Salinas, Felipe S.
AU - Papanastassiou, Alex M.
AU - Szabó, C. Ákos
N1 - Funding Information:
This study was supported by an investigator-initiated grant through Lundbeck, Inc. , and used primate resources supported by [ P51 OD011133 ], and was conducted in facilities constructed with support from Research Facilities Improvement Grants [ C06 RR013556 , C06 RR014578 , and C06 RR015456 ]. This study was presented at the 2017 American Epilepsy Society Meeting in Washington DC.
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/9
Y1 - 2019/9
N2 - The epileptic baboon provides a natural model of idiopathic generalized epilepsy and sudden unexpected death in epilepsy (SUDEP). We sought to evaluate autonomic differences, including heart rate (HR), heart rate variability (HRV) and corrected QT-duration (QTc) between two epileptic (EB1, EB2) and one control (CB) baboon, and the autonomic effects of high-frequency (HF) microburst Vagal Nerve Stimulation (VNS) Therapy in the epileptic baboons. At baseline, EB2′s HR was increased over both EB1 and CB, and EB1′s HRV was decreased compared to the others. QTc-intervals were significantly prolonged in both epileptic baboons. EB1 became free of generalized tonic-clonic seizures (GTCS) with VNS therapy, whereas EB2′s GTCS were reduced by a third. HR decreased in both epileptic baboons, but while HRV improved in EB1, it decreased in EB2. EB2 succumbed to SUDEP after 9 months. This pilot study demonstrates abnormalities in HR, HRV and QTc-intervals in epileptic baboons. HF VNS Therapy demonstrated different effects on HRV in the two epileptic baboons, which, in addition to persistent GTCS and elevated HR, may have contributed to SUDEP risk in EB2. Future studies are needed to establish normative values for HRV and determine variability of HR, HRV and QTc-intervals in epileptic baboons.
AB - The epileptic baboon provides a natural model of idiopathic generalized epilepsy and sudden unexpected death in epilepsy (SUDEP). We sought to evaluate autonomic differences, including heart rate (HR), heart rate variability (HRV) and corrected QT-duration (QTc) between two epileptic (EB1, EB2) and one control (CB) baboon, and the autonomic effects of high-frequency (HF) microburst Vagal Nerve Stimulation (VNS) Therapy in the epileptic baboons. At baseline, EB2′s HR was increased over both EB1 and CB, and EB1′s HRV was decreased compared to the others. QTc-intervals were significantly prolonged in both epileptic baboons. EB1 became free of generalized tonic-clonic seizures (GTCS) with VNS therapy, whereas EB2′s GTCS were reduced by a third. HR decreased in both epileptic baboons, but while HRV improved in EB1, it decreased in EB2. EB2 succumbed to SUDEP after 9 months. This pilot study demonstrates abnormalities in HR, HRV and QTc-intervals in epileptic baboons. HF VNS Therapy demonstrated different effects on HRV in the two epileptic baboons, which, in addition to persistent GTCS and elevated HR, may have contributed to SUDEP risk in EB2. Future studies are needed to establish normative values for HRV and determine variability of HR, HRV and QTc-intervals in epileptic baboons.
KW - Baboon
KW - Epilepsy
KW - Heart rate variability
KW - High-frequency microburst VNS therapy
KW - QT-intervals
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U2 - 10.1016/j.eplepsyres.2019.106156
DO - 10.1016/j.eplepsyres.2019.106156
M3 - Article
C2 - 31284120
AN - SCOPUS:85068371881
VL - 155
JO - Journal of Epilepsy
JF - Journal of Epilepsy
SN - 0920-1211
M1 - 106156
ER -