Cardiac autonomic denervation and functional response to neurotoxins during acute experimental Chagas' disease in rats

A. L. Teixeira; B. F. Fontoura; L. Freire-Maia; E. Chiari; C. R.S. Machado; M. M. Teixeira; E. R.S. Camargos

doi:10.1016/S1566-0702(01)00245-4

Cardiac autonomic denervation and functional response to neurotoxins during acute experimental Chagas' disease in rats

A. L. Teixeira, B. F. Fontoura, L. Freire-Maia, E. Chiari, C. R.S. Machado, M. M. Teixeira, E. R.S. Camargos

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Severe cardiac autonomic denervation occurs in the acute Chagas' disease in rats. The present study aims at verifying whether this denervation was accompanied by impairment of heart function. Scorpionic (Tityus serrulatus) crude venom was used for neurotransmitter release in isolated hearts (Langendorff's preparation). In control hearts, the venom induced significant bradycardia followed by tachycardia. In infected animals, despite the severe (sympathetic) or moderate (parasympathetic) cardiac denervation, the venom provoked similar bradycardia but the tachycardia was higher. The hearts of infected animals beat at significantly lower rate. Atropine prevented this lower rate. Our results demonstrated sympathetic dysfunction during the acute phase of Trypanosoma cruzi infection in rats, the parasympathetic function being spared.

Original language	English (US)
Pages (from-to)	128-132
Number of pages	5
Journal	Autonomic Neuroscience: Basic and Clinical
Volume	89
Issue number	1-2
DOIs	https://doi.org/10.1016/S1566-0702(01)00245-4
State	Published - Jun 20 2001
Externally published	Yes

Keywords

Autonomic denervation
Chagas' disease
Heart
Scorpion venom

ASJC Scopus subject areas

Endocrine and Autonomic Systems
Clinical Neurology
Cellular and Molecular Neuroscience

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10.1016/S1566-0702(01)00245-4

Cite this

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title = "Cardiac autonomic denervation and functional response to neurotoxins during acute experimental Chagas' disease in rats",

abstract = "Severe cardiac autonomic denervation occurs in the acute Chagas' disease in rats. The present study aims at verifying whether this denervation was accompanied by impairment of heart function. Scorpionic (Tityus serrulatus) crude venom was used for neurotransmitter release in isolated hearts (Langendorff's preparation). In control hearts, the venom induced significant bradycardia followed by tachycardia. In infected animals, despite the severe (sympathetic) or moderate (parasympathetic) cardiac denervation, the venom provoked similar bradycardia but the tachycardia was higher. The hearts of infected animals beat at significantly lower rate. Atropine prevented this lower rate. Our results demonstrated sympathetic dysfunction during the acute phase of Trypanosoma cruzi infection in rats, the parasympathetic function being spared.",

keywords = "Autonomic denervation, Chagas' disease, Heart, Scorpion venom",

author = "Teixeira, {A. L.} and Fontoura, {B. F.} and L. Freire-Maia and E. Chiari and Machado, {C. R.S.} and Teixeira, {M. M.} and Camargos, {E. R.S.}",

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T1 - Cardiac autonomic denervation and functional response to neurotoxins during acute experimental Chagas' disease in rats

AU - Teixeira, A. L.

AU - Fontoura, B. F.

AU - Freire-Maia, L.

AU - Chiari, E.

AU - Machado, C. R.S.

AU - Teixeira, M. M.

AU - Camargos, E. R.S.

PY - 2001/6/20

Y1 - 2001/6/20

N2 - Severe cardiac autonomic denervation occurs in the acute Chagas' disease in rats. The present study aims at verifying whether this denervation was accompanied by impairment of heart function. Scorpionic (Tityus serrulatus) crude venom was used for neurotransmitter release in isolated hearts (Langendorff's preparation). In control hearts, the venom induced significant bradycardia followed by tachycardia. In infected animals, despite the severe (sympathetic) or moderate (parasympathetic) cardiac denervation, the venom provoked similar bradycardia but the tachycardia was higher. The hearts of infected animals beat at significantly lower rate. Atropine prevented this lower rate. Our results demonstrated sympathetic dysfunction during the acute phase of Trypanosoma cruzi infection in rats, the parasympathetic function being spared.

AB - Severe cardiac autonomic denervation occurs in the acute Chagas' disease in rats. The present study aims at verifying whether this denervation was accompanied by impairment of heart function. Scorpionic (Tityus serrulatus) crude venom was used for neurotransmitter release in isolated hearts (Langendorff's preparation). In control hearts, the venom induced significant bradycardia followed by tachycardia. In infected animals, despite the severe (sympathetic) or moderate (parasympathetic) cardiac denervation, the venom provoked similar bradycardia but the tachycardia was higher. The hearts of infected animals beat at significantly lower rate. Atropine prevented this lower rate. Our results demonstrated sympathetic dysfunction during the acute phase of Trypanosoma cruzi infection in rats, the parasympathetic function being spared.

KW - Autonomic denervation

KW - Chagas' disease

KW - Heart

KW - Scorpion venom

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JF - Autonomic Neuroscience: Basic and Clinical

IS - 1-2

ER -

Cardiac autonomic denervation and functional response to neurotoxins during acute experimental Chagas' disease in rats

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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