Carbaryl-induced changes in indoleamine synthesis in the pineal gland and its effects on nighttime serum melatonin concentrations

A. M. Attia, Russel J Reiter, K. O. Nonaka, M. H. Mostafa, S. A. Soliman, A. H. El-Sebae

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effects of different doses of chronically administered carbaryl on rat pineal N-acetyltransferase (NAT) activity, hydroxyindole-O-methyltransferase (HIOMT) activity and pineal and serum melatonin levels during darkness (2300 h and 0100 h) when pineal melatonin synthesis is high were studied. Additionally, pineal levels of 5-hydroxytryptophan (5-HTP), serotonin (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) were estimated. Carbaryl was administered at total doses (over 6 days) of either 50, 125 or 250 mg/kg by gastric gavage. Control rats received vehicle (corn oil) only. During the study, the rats were exposed to light/dark cycles of 14:10 with lights off at 2100 h. Pineal NAT and HIOMT activities and pineal melatonin were increased at 0100 h following carbaryl administration at all three doses. Conversely, serum melatonin was increased at 2300 h after the 250 mg/kg dose of carbaryl while all three doses of the pesticide reduced serum melatonin levels at 0100 h. Pineal 5-HTP, 5-HT and 5-HIAA levels were usually increased at 2300 h but unaffected at 0100 h. The results indicate that carbaryl has significant effects on pineal melatonin synthesis and secretion.

Original languageEnglish (US)
Pages (from-to)305-314
Number of pages10
JournalToxicology
Volume65
Issue number3
DOIs
StatePublished - 1991

Fingerprint

Carbaryl
Pineal Gland
Melatonin
Acetylserotonin O-Methyltransferase
Serum
5-Hydroxytryptophan
Serotonin
Acetyltransferases
Acetic Acid
Rats
Rat control
Corn Oil
Darkness
Photoperiod
Pesticides
Stomach
Light

Keywords

  • Carbaryl
  • Hydroxyindole-O-methyltransferase activity
  • Indolamines
  • Melatonin
  • N-acetyltransferase activity
  • Pineal gland
  • Serotonin

ASJC Scopus subject areas

  • Toxicology

Cite this

Carbaryl-induced changes in indoleamine synthesis in the pineal gland and its effects on nighttime serum melatonin concentrations. / Attia, A. M.; Reiter, Russel J; Nonaka, K. O.; Mostafa, M. H.; Soliman, S. A.; El-Sebae, A. H.

In: Toxicology, Vol. 65, No. 3, 1991, p. 305-314.

Research output: Contribution to journalArticle

Attia, A. M. ; Reiter, Russel J ; Nonaka, K. O. ; Mostafa, M. H. ; Soliman, S. A. ; El-Sebae, A. H. / Carbaryl-induced changes in indoleamine synthesis in the pineal gland and its effects on nighttime serum melatonin concentrations. In: Toxicology. 1991 ; Vol. 65, No. 3. pp. 305-314.
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