Captopril modifies the hemodynamic and neuroendocrine responses to sodium nitroprusside in hypertensive patients

William A. Clementi, Nancy L. Durst, John L. McNay, T. Kent Keeton

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

To determine if clinically effective doses of the antihypertensive agent captopril affected the neuronal release of norepinephrine or baroreflex sensitivity, changes in plasma norepinephrine concentration and heart rate were related to the changes in mean arterial pressure seen during the intravenous infusion of stepwise incremental doses of sodium nitroprusside before and during captopril treatment in eight hypertensive men with normal or low plasma renin activity. At all times, significant linear correlations were found between 1) the decrease in mean arterial pressure and the dose of sodium nitroprusside, 2) the increase in heart rate and the decrease in mean arterial pressure, and 3) the increase in plasma norepinephrine concentration and the decrease in mean arterial pressure. When the subjects were treated with captopril (25 mg t.i.d.) for 2 to 4 weeks, supine mean arterial pressure decreased from 130 to 114 mm Hg (-12%; p < 0.05), heart rate did not change, supine and upright plasma renin activity increased, while supine plasma norepinephrine and epinephrine concentration decreased slightly. Therapy with captopril (25 mg t.i.d.) increased baroreflex sensitivity, as assessed by the slope of the regression line relating the increase in heart rate to the decrease in mean arterial pressure, and increased the responsiveness of the sympathetic nervous system, as assessed by the slope of the regression line relating the increase in plasma norepinephrine concentration to the decrease in mean arterial pressure. These increases were accompanied by a decrease in the slope of the regression line relating the decrease in mean arterial pressure to the dose of sodium nitroprusside and thus were associated with a decreased sensitivity to the vasodepressor effects of sodium nitroprusside. These observations suggest that captopril's antihypertensive mechanism of action in hypertensive subjects with normal or low plasma renin activity does not involve an impairment of the sympathetic neuronal release of norepinephrine.

Original languageEnglish (US)
Pages (from-to)229-237
Number of pages9
JournalHypertension
Volume8
Issue number3
DOIs
StatePublished - Mar 1986
Externally publishedYes

Keywords

  • Angiotensin converting enzyme inhibition
  • Baroreflex sensitivity
  • Plasma norepinephrine concentration
  • Renin-angiotensin system
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Internal Medicine

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