Capillarity and blood flow of transplanted skeletal muscles of cats

T. P. White, L. C. Maxwell, D. M. Sosin, J. A. Faulker

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

After transplantation, skeletal muscle fibers and the microvasculature degenerate and then regenerate. The structural and functional characteristics of autografted muscle change with time and ultimately stabilize. Capillarity, blood flow, or fatigability was measured in control (total n=22) and in autografted (total n=42) extensor digitorum longus muscles of cats. From 10 to 180 days after transplantation, the capillaries per square millimeter in peripheral areas of autografts averaged 65% of control, and from 180 to 518 days, 45% of control. Resting blood flow in autografts increased eventually from total ischemia at the time of transplantation to values 400% of control. After 400 days, resting blood flow returned to control values. The blood flow of autografts increased in response to twitch stimulation, reaching maximal values (24.4±1.4 ml.100 g-1,min-1) at 1 twitch.s-1. The maximal blood flow of autografts was comparable to the submaximal blood flow at 1 twitch.s-1 of controls and was 30% of the maximal flow of controls obtained at 4 twitches.s-1. The maximal blood flow in autografts did not increase from 80 to 460 days. When stimulated with repetitive twitches, autografts fatigued more rapidly than controls.

Original languageEnglish (US)
Pages (from-to)630-636
Number of pages7
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume10
Issue number4
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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