Cannabinoid modulation of dopaminergic circuits in neurodegenerative and neuropsychiatric disorders

Julien Matricon, Andrea Giuffrida

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


The endocannabinoid system timely orchestrates a variety of cerebral physiological processes by modulating brain neurotransmitters, and in particular the dopamine system. Both endocannabinoid and dopamine receptors are highly abundant and often coexpressed in the basal ganglia and mesolimbic pathways, where they regulate motor functions and motivational aspects of behavior. Understanding the interrelationship between these two systems is crucial to gain new insight on the pathophysiology of brain disorders characterized by a dysregulation of dopamine, such as Parkinson's disease and schizophrenia. This review aims at: (1) presenting the complex functional interactions between these two neurotransmitter systems at the anatomical, pharmacological, cellular and electrophysiological levels, and (2) addressing the contribution of disturbances of cannabinoid-dopamine interactions to neurodegenerative and psychiatric disorders.

Original languageEnglish (US)
Title of host publicationEndocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders
PublisherSpringer New York
Number of pages29
ISBN (Electronic)9781461479406
ISBN (Print)1461479398, 9781461479390
StatePublished - Nov 1 2013


  • CB1
  • Dopamine
  • Dyskinesia
  • Endocannabinoid
  • Parkinson's disease
  • Schizophrenia
  • Signaling
  • Social behavior

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience


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