Candidate gene association analysis of acute lymphoblastic leukemia identifies new susceptibility locus at 11p15 (LMO1)

Joke Beuten; Jonathan A.L. Gelfond; Duangjai Piwkham; Brad H. Pollock; Naomi J. Winick; Anderson B. Collier; Gail E. Tomlinson

doi:10.1093/carcin/bgr091

Candidate gene association analysis of acute lymphoblastic leukemia identifies new susceptibility locus at 11p15 (LMO1)

Joke Beuten
, Jonathan A.L. Gelfond
, Duangjai Piwkham
, Brad H. Pollock
, Naomi J. Winick
, Anderson B. Collier
, Gail E. Tomlinson

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

To determine the contribution of susceptibility loci in explaining the genetic basis of acute lymphoblastic leukemia (ALL), we genotyped 29 high-potential candidate genes with 672 tagged single-nucleotide polymorphisms (SNPs) in a sample (163 cases and 251 healthy controls) of Caucasian children. Fifty SNPs in 15 genes were significantly associated with ALL risk at the P < 0.05 level. After correction for multiple testing, rs442264 within the LIM domain only 1 (LMO1) gene at 11p15 remained significant [odds ratio (OR) = 1.90, P= 3× 10^-5]. In addition, a major haplotype within LMO1 comprising 14 SNPs with individual risk associations was found to significantly increase ALL risk (OR 5 1.79, P 5 0.0006). A stratified analysis on subtype indicated that risk associations of LMO1 variants are significant in children with precursor B-cell leukemia. These data show that genetic variants within LMO1 are associated with ALL and identify this gene as a strong candidate for precursor B-cell leukemogenesis.

Original language	English (US)
Pages (from-to)	1349-1353
Number of pages	5
Journal	Carcinogenesis
Volume	32
Issue number	9
DOIs	https://doi.org/10.1093/carcin/bgr091
State	Published - Sep 2011

ASJC Scopus subject areas

Cancer Research

Access to Document

10.1093/carcin/bgr091

Cite this

@article{9fa8ea8893fd449ebd16830e08db1c3e,

title = "Candidate gene association analysis of acute lymphoblastic leukemia identifies new susceptibility locus at 11p15 (LMO1)",

abstract = "To determine the contribution of susceptibility loci in explaining the genetic basis of acute lymphoblastic leukemia (ALL), we genotyped 29 high-potential candidate genes with 672 tagged single-nucleotide polymorphisms (SNPs) in a sample (163 cases and 251 healthy controls) of Caucasian children. Fifty SNPs in 15 genes were significantly associated with ALL risk at the P < 0.05 level. After correction for multiple testing, rs442264 within the LIM domain only 1 (LMO1) gene at 11p15 remained significant [odds ratio (OR) = 1.90, P= 3× 10-5]. In addition, a major haplotype within LMO1 comprising 14 SNPs with individual risk associations was found to significantly increase ALL risk (OR 5 1.79, P 5 0.0006). A stratified analysis on subtype indicated that risk associations of LMO1 variants are significant in children with precursor B-cell leukemia. These data show that genetic variants within LMO1 are associated with ALL and identify this gene as a strong candidate for precursor B-cell leukemogenesis.",

author = "Joke Beuten and Gelfond, \{Jonathan A.L.\} and Duangjai Piwkham and Pollock, \{Brad H.\} and Winick, \{Naomi J.\} and Collier, \{Anderson B.\} and Tomlinson, \{Gail E.\}",

note = "Funding Information: Hyundai Hope on Wheels [44096 to J.B. and G.E.T.]; the Texas Higher Education Coordinating Board [010019-0105-2001 to G.E.T.]; the Children{\textquoteright}s Cancer Fund Dallas to G.E.T.; the Greehey Family Foundation to G.E.T. and the Commission on Higher Education Scholarship, Thailand, to D.P.",

year = "2011",

month = sep,

doi = "10.1093/carcin/bgr091",

language = "English (US)",

volume = "32",

pages = "1349--1353",

journal = "Carcinogenesis",

issn = "0143-3334",

publisher = "Oxford University Press",

number = "9",

}

TY - JOUR

T1 - Candidate gene association analysis of acute lymphoblastic leukemia identifies new susceptibility locus at 11p15 (LMO1)

AU - Beuten, Joke

AU - Gelfond, Jonathan A.L.

AU - Piwkham, Duangjai

AU - Pollock, Brad H.

AU - Winick, Naomi J.

AU - Collier, Anderson B.

AU - Tomlinson, Gail E.

N1 - Funding Information: Hyundai Hope on Wheels [44096 to J.B. and G.E.T.]; the Texas Higher Education Coordinating Board [010019-0105-2001 to G.E.T.]; the Children’s Cancer Fund Dallas to G.E.T.; the Greehey Family Foundation to G.E.T. and the Commission on Higher Education Scholarship, Thailand, to D.P.

PY - 2011/9

Y1 - 2011/9

N2 - To determine the contribution of susceptibility loci in explaining the genetic basis of acute lymphoblastic leukemia (ALL), we genotyped 29 high-potential candidate genes with 672 tagged single-nucleotide polymorphisms (SNPs) in a sample (163 cases and 251 healthy controls) of Caucasian children. Fifty SNPs in 15 genes were significantly associated with ALL risk at the P < 0.05 level. After correction for multiple testing, rs442264 within the LIM domain only 1 (LMO1) gene at 11p15 remained significant [odds ratio (OR) = 1.90, P= 3× 10-5]. In addition, a major haplotype within LMO1 comprising 14 SNPs with individual risk associations was found to significantly increase ALL risk (OR 5 1.79, P 5 0.0006). A stratified analysis on subtype indicated that risk associations of LMO1 variants are significant in children with precursor B-cell leukemia. These data show that genetic variants within LMO1 are associated with ALL and identify this gene as a strong candidate for precursor B-cell leukemogenesis.

AB - To determine the contribution of susceptibility loci in explaining the genetic basis of acute lymphoblastic leukemia (ALL), we genotyped 29 high-potential candidate genes with 672 tagged single-nucleotide polymorphisms (SNPs) in a sample (163 cases and 251 healthy controls) of Caucasian children. Fifty SNPs in 15 genes were significantly associated with ALL risk at the P < 0.05 level. After correction for multiple testing, rs442264 within the LIM domain only 1 (LMO1) gene at 11p15 remained significant [odds ratio (OR) = 1.90, P= 3× 10-5]. In addition, a major haplotype within LMO1 comprising 14 SNPs with individual risk associations was found to significantly increase ALL risk (OR 5 1.79, P 5 0.0006). A stratified analysis on subtype indicated that risk associations of LMO1 variants are significant in children with precursor B-cell leukemia. These data show that genetic variants within LMO1 are associated with ALL and identify this gene as a strong candidate for precursor B-cell leukemogenesis.

UR - https://www.scopus.com/pages/publications/80052409831

UR - https://www.scopus.com/pages/publications/80052409831#tab=citedBy

U2 - 10.1093/carcin/bgr091

DO - 10.1093/carcin/bgr091

M3 - Article

C2 - 21602560

AN - SCOPUS:80052409831

SN - 0143-3334

VL - 32

SP - 1349

EP - 1353

JO - Carcinogenesis

JF - Carcinogenesis

IS - 9

ER -

Candidate gene association analysis of acute lymphoblastic leukemia identifies new susceptibility locus at 11p15 (LMO1)

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this