Candida albicans meningitis in a premature neonate successfully treated with 5-fluorocytosine and amphotericin B: A case report and review of the literature

L. D. Lilien, R. S. Ramamurthy, R. S. Pildes

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Candida albicans meningitis was diagnosed in a 45-day-old premature infant whose birth weight was 1,616 gm. Symptoms consisted of poor weight gain and poor sucking. The combined use of amphotericin B and 5-fluorocytosine (5-FC) resulted in negative CSF cultures after 12 days of therapy. Amphotericin B was given for 45 days (total 83 mg) and 5-FC for 60 days (total 19 mg). Only one other premature infant has been reported in the literature who had similar treatment. A review of Candida meningitis diagnosed before death in 11 other infants less than 1 year of age is presented.

Original languageEnglish (US)
Pages (from-to)57-61
Number of pages5
JournalPediatrics
Volume61
Issue number1
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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