Candida albicans meningitis in a premature neonate successfully treated with 5-fluorocytosine and amphotericin B: A case report and review of the literature

L. D. Lilien, R. S. Ramamurthy, R. S. Pildes

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Candida albicans meningitis was diagnosed in a 45-day-old premature infant whose birth weight was 1,616 gm. Symptoms consisted of poor weight gain and poor sucking. The combined use of amphotericin B and 5-fluorocytosine (5-FC) resulted in negative CSF cultures after 12 days of therapy. Amphotericin B was given for 45 days (total 83 mg) and 5-FC for 60 days (total 19 mg). Only one other premature infant has been reported in the literature who had similar treatment. A review of Candida meningitis diagnosed before death in 11 other infants less than 1 year of age is presented.

Original languageEnglish (US)
Pages (from-to)57-61
Number of pages5
JournalPediatrics
Volume61
Issue number1
StatePublished - 1978
Externally publishedYes

Fingerprint

Flucytosine
Amphotericin B
Candida albicans
Meningitis
Premature Infants
Newborn Infant
Candida
Birth Weight
Weight Gain
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Candida albicans meningitis in a premature neonate successfully treated with 5-fluorocytosine and amphotericin B : A case report and review of the literature. / Lilien, L. D.; Ramamurthy, R. S.; Pildes, R. S.

In: Pediatrics, Vol. 61, No. 1, 1978, p. 57-61.

Research output: Contribution to journalArticle

@article{e03b107e92a941e897a6f0df72f60e25,
title = "Candida albicans meningitis in a premature neonate successfully treated with 5-fluorocytosine and amphotericin B: A case report and review of the literature",
abstract = "Candida albicans meningitis was diagnosed in a 45-day-old premature infant whose birth weight was 1,616 gm. Symptoms consisted of poor weight gain and poor sucking. The combined use of amphotericin B and 5-fluorocytosine (5-FC) resulted in negative CSF cultures after 12 days of therapy. Amphotericin B was given for 45 days (total 83 mg) and 5-FC for 60 days (total 19 mg). Only one other premature infant has been reported in the literature who had similar treatment. A review of Candida meningitis diagnosed before death in 11 other infants less than 1 year of age is presented.",
author = "Lilien, {L. D.} and Ramamurthy, {R. S.} and Pildes, {R. S.}",
year = "1978",
language = "English (US)",
volume = "61",
pages = "57--61",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "1",

}

TY - JOUR

T1 - Candida albicans meningitis in a premature neonate successfully treated with 5-fluorocytosine and amphotericin B

T2 - A case report and review of the literature

AU - Lilien, L. D.

AU - Ramamurthy, R. S.

AU - Pildes, R. S.

PY - 1978

Y1 - 1978

N2 - Candida albicans meningitis was diagnosed in a 45-day-old premature infant whose birth weight was 1,616 gm. Symptoms consisted of poor weight gain and poor sucking. The combined use of amphotericin B and 5-fluorocytosine (5-FC) resulted in negative CSF cultures after 12 days of therapy. Amphotericin B was given for 45 days (total 83 mg) and 5-FC for 60 days (total 19 mg). Only one other premature infant has been reported in the literature who had similar treatment. A review of Candida meningitis diagnosed before death in 11 other infants less than 1 year of age is presented.

AB - Candida albicans meningitis was diagnosed in a 45-day-old premature infant whose birth weight was 1,616 gm. Symptoms consisted of poor weight gain and poor sucking. The combined use of amphotericin B and 5-fluorocytosine (5-FC) resulted in negative CSF cultures after 12 days of therapy. Amphotericin B was given for 45 days (total 83 mg) and 5-FC for 60 days (total 19 mg). Only one other premature infant has been reported in the literature who had similar treatment. A review of Candida meningitis diagnosed before death in 11 other infants less than 1 year of age is presented.

UR - http://www.scopus.com/inward/record.url?scp=0017843288&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017843288&partnerID=8YFLogxK

M3 - Article

C2 - 263875

AN - SCOPUS:0017843288

VL - 61

SP - 57

EP - 61

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 1

ER -