TY - JOUR
T1 - Cancer type-specific modulation of mitochondrial haplogroups in breast, colorectal and thyroid cancer
AU - Fang, Hezhi
AU - Shen, Lijun
AU - Chen, Tao
AU - He, Jing
AU - Ding, Zhinan
AU - Wei, Jia
AU - Qu, Jianchun
AU - Chen, Guorong
AU - Lu, Jianxin
AU - Bai, Yidong
N1 - Funding Information:
This work is supported by Zhejiang provincial top key discipline of laboratory medicine, Zhejiang provincial program for the cultivation of high level innovative health talents, and National Science Foundation of China (No. 30800620). Yidong Bai is supported by a NIH grant (R01 AG025223).
PY - 2010/8/12
Y1 - 2010/8/12
N2 - Background: Mitochondrial DNA (mtDNA) haplogroups and single nucleotide polymorphisms (mtSNP) have been shown to play a role in various human conditions including aging and some neurodegenerative diseases, metabolic diseases and cancer.Methods: To investigate whether mtDNA haplogroups contribute to the occurrence of cancer in a specific Chinese population, we have carried out a comprehensive case-control study of mtDNA from large cohorts of patients with three common cancer types, namely, colorectal cancer (n = 108), thyroid cancer (n = 100) and breast cancer (n = 104), in Wenzhou, a southern Chinese city in the Zhejiang Province.Results: We found that patients with mtDNA haplogroup M exhibited an increased risk of breast cancer occurrence [OR = 1.77; 95% CI (1.03-3.07); P = 0.040], and that this risk was even more pronounced in a sub-haplogroup of M, D5 [OR = 3.11; 95%CI (1.07-9.06); p = 0.030]. In spite of this, in patients with breast cancer, haplogroup M was decreased in the metastatic group. On the other hand, our results also showed that haplogroup D4a was associated with an increased risk of thyroid cancer [OR = 3.00; 95%CI (1.09-8.29); p = 0.028]. However, no significant correlation has been detected between any mtDNA haplogroups and colorectal cancer occurrence.Conclusion: Our investigation indicates that mitochondrial haplogroups could have a tissue-specific, population-specific and stage-specific role in modulating cancer development.
AB - Background: Mitochondrial DNA (mtDNA) haplogroups and single nucleotide polymorphisms (mtSNP) have been shown to play a role in various human conditions including aging and some neurodegenerative diseases, metabolic diseases and cancer.Methods: To investigate whether mtDNA haplogroups contribute to the occurrence of cancer in a specific Chinese population, we have carried out a comprehensive case-control study of mtDNA from large cohorts of patients with three common cancer types, namely, colorectal cancer (n = 108), thyroid cancer (n = 100) and breast cancer (n = 104), in Wenzhou, a southern Chinese city in the Zhejiang Province.Results: We found that patients with mtDNA haplogroup M exhibited an increased risk of breast cancer occurrence [OR = 1.77; 95% CI (1.03-3.07); P = 0.040], and that this risk was even more pronounced in a sub-haplogroup of M, D5 [OR = 3.11; 95%CI (1.07-9.06); p = 0.030]. In spite of this, in patients with breast cancer, haplogroup M was decreased in the metastatic group. On the other hand, our results also showed that haplogroup D4a was associated with an increased risk of thyroid cancer [OR = 3.00; 95%CI (1.09-8.29); p = 0.028]. However, no significant correlation has been detected between any mtDNA haplogroups and colorectal cancer occurrence.Conclusion: Our investigation indicates that mitochondrial haplogroups could have a tissue-specific, population-specific and stage-specific role in modulating cancer development.
UR - https://www.scopus.com/pages/publications/77955384590
UR - https://www.scopus.com/pages/publications/77955384590#tab=citedBy
U2 - 10.1186/1471-2407-10-421
DO - 10.1186/1471-2407-10-421
M3 - Article
C2 - 20704735
AN - SCOPUS:77955384590
SN - 1471-2407
VL - 10
JO - BMC Cancer
JF - BMC Cancer
M1 - 421
ER -