Cancer therapy using natural ligands that target estrogen receptor beta

Gangadhara R Sareddy, Ratna K Vadlamudi

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Estrogen receptor beta (ERβ) is one of the two key receptors (ERα, ERβ) that facilitate biological actions of 17β-estradiol (E2). ERβ is widely expressed in many tissues, and its expression is reduced or lost during progression of many tumors. ERβ facilitates estrogen signaling by both genomic (classical and non-classical) and extra-nuclear signaling. Emerging evidence suggests that ERβ functions as a tissue-specific tumor suppressor with anti-proliferative actions. Recent studies have identified a number of naturally available selective ERβ agonists. Targeting ERβ using its naturally available ligands is an attractive approach for treating and preventing cancers. This review presents the beneficial actions of ERβ signaling and clinical utility of several natural ERβ ligands as potential cancer therapy.

Original languageEnglish (US)
Pages (from-to)801-807
Number of pages7
JournalChinese Journal of Natural Medicines
Volume13
Issue number11
DOIs
StatePublished - Nov 1 2015

Keywords

  • ER beta agonists
  • Estrogen receptor
  • Estrogen receptor beta
  • Genistein
  • Liquiritigenin
  • S-equol
  • Tumor suppressor

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Drug Discovery

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