Cancer mutation signatures, DNA damage mechanisms, and potential clinical implications

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Knowledge of cancer genomic DNA sequences has created unprecedented opportunities for mutation studies. Computational analyses have begun to decipher mutational signatures that identify underlying causes. A recent analysis encompassing 30 cancer types reported 20 distinct mutation signatures, resulting from ultraviolet light, deficiencies in DNA replication and repair, and unexpectedly large contributions from both spontaneous and APOBEC-catalyzed DNA cytosine deamination. Mutational signatures have the potential to become diagnostic, prognostic, and therapeutic biomarkers as well as factors in therapy development.

Original languageEnglish (US)
Article number87
JournalGenome Medicine
Volume5
Issue number9
DOIs
StatePublished - Sep 27 2013
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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