Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice

Jessica M. Snyder, Kerriann M. Casey, Andrzej Galecki, David E. Harrison, Hashan Jayarathne, Navasuja Kumar, Francesca Macchiarini, Nadia Rosenthal, Marianna Sadagurski, Adam B. Salmon, Randy Strong, Richard A. Miller, Warren Ladiges

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Canagliflozin (Cana), a clinically important anti-diabetes drug, leads to a 14% increase in median lifespan and a 9% increase in the 90th percentile age when given to genetically heterogeneous male mice from 7 months of age, but does not increase lifespan in female mice. A histopathological study was conducted on 22-month-old mice to see if Cana retarded diverse forms of age-dependent pathology. This agent was found to diminish incidence or severity, in male mice only, of cardiomyopathy, glomerulonephropathy, arteriosclerosis, hepatic microvesicular cytoplasmic vacuolation (lipidosis), and adrenal cortical neoplasms. Protection against atrophy of the exocrine pancreas was seen in both males and females. Thus, the extension of lifespan in Cana-treated male mice, which is likely to reflect host- or tumor-mediated delay in lethal neoplasms, is accompanied by parallel retardation of lesions, in multiple tissues, that seldom if ever lead to death in these mice. Canagliflozin thus can be considered a drug that acts to slow the aging process and should be evaluated for potential protective effects against many other late-life conditions.

Original languageEnglish (US)
JournalGeroScience
DOIs
StateAccepted/In press - 2022

Keywords

  • Age-related pathology
  • Canagliflozin
  • ITP
  • Lifespan
  • Sexual dimorphism

ASJC Scopus subject areas

  • Aging
  • veterinary (miscalleneous)
  • Complementary and alternative medicine
  • Geriatrics and Gerontology
  • Cardiology and Cardiovascular Medicine

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