Can the DRL 72s schedule selectively reveal antidepressant drug activity?

A. Jackson, W. Koek, F. C. Colpaert

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The effects of three antidepressants, desipramine (2.5-20 mg/kg) tranylcypromine (0.63-2.5 mg/kg) mianserin (1.25-10 mg/kg) and three non-antidepressants, chlordiazepoxide (CDP; 1.25-10 mg/kg) haloperidol (0.02-0.16 mg/kg)d-amphetamine (0.31-1.25 mg/kg) were evaluated in rats responding for water reinforcement under a DRL 72s schedule. The antidepressants all produced dose-related decreases in overall response rates, but no significant changes in reinforcement frequency. In contrast, the anxiolytic CDP did increase the number of reinforcers obtained. Haloperidol decreased both reinforcers and responses whilst d-amphetamine stimulated responding, thereby decreasing reinforcement frequency. An analysis of the modes of inter-response times (IRTs) revealed no significant shifts in the peaks of the IRT distributions for most of the drugs tested. Amphetamine, however, (0.31 and 0.63 mg/kg) decreased the modal values in correspondence with the shift to the left of the peak of responding caused by this compound. These results are discussed in the context of the use of the DRL 72s procedure as a screening test for antidepressant drugs.

Original languageEnglish (US)
Pages (from-to)154-161
Number of pages8
JournalPsychopharmacology
Volume117
Issue number2
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Keywords

  • Antidepressants
  • Chlordiazepoxide d-Amphetamine
  • DRL 72s schedule Water reinforcement
  • Haloperidol
  • Rat

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Can the DRL 72s schedule selectively reveal antidepressant drug activity?'. Together they form a unique fingerprint.

  • Cite this