Can oral health and oral-derived biospecimens predict progression of dementia?

Miranda E. Orr, Kelly R. Reveles, Chih Ko Yeh, Eric H. Young, Xianlin Han

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Growing evidence indicates that oral health and brain health are interconnected. Declining cognition and dementia coincide with lack of self-preservation, including oral hygiene. The oral microbiota plays an important role in maintaining oral health. Emerging evidence suggests a link between oral dysbiosis and cognitive decline in patients with Alzheimer's disease. This review showcases the recent advances connecting oral health and cognitive function during aging and the potential utility of oral-derived biospecimens to inform on brain health. Collectively, experimental findings indicate that the connection between oral health and cognition cannot be underestimated; moreover, oral biospecimens are abundant and readily obtainable without invasive procedures, which may help inform on cognitive health.

Original languageEnglish (US)
Pages (from-to)249-258
Number of pages10
JournalOral Diseases
Issue number2
StatePublished - Mar 1 2020


  • Alzheimer's disease
  • dementia
  • oral health
  • oral microbiome
  • saliva lipidomics
  • volatile organic compounds

ASJC Scopus subject areas

  • Dentistry(all)
  • Otorhinolaryngology


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