CaMKII autophosphorylation-dependent learning and memory

Calcium/calmodulin-dependent kinase II is the most abundant protein in the post-synaptic density. It has been proposed to play an important role on learning and memory due to its autophosphorylation ability. Once phosphorylated in the right position CaMKII remains active even after the initial stimulus has fi nished. Although the model seems quite logical and straight forward the function of CaMKII autophosphorylation in learning and memory is still a matter of discussion. While its importance in learning is well established there isn’t still enough data to reach a conclusion on memory. In this chapter we will discuss CaMKII autophosphorylation theory, its importance for LTP, learning, memory and possible relevance in different diseases.