Calvarial bone regeneration using osteogenin

J. Hollinger, D. E. Mark, D. E. Bach, A. H. Reddi, A. E. Seyfer

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


This experimental study reports on the application of a partially purified noncollagenous protein extracted from cortical bone to restore craniotomy defects in Papio species (baboon). The partially purified protein (osteogenin) produced significantly more bone formation in calvarial wounds than was found in the untreated controls. There were no adverse tissue reactions from the implanted xenogeneic osteogenin.

Original languageEnglish (US)
Pages (from-to)1182-1186
Number of pages5
JournalJournal of Oral and Maxillofacial Surgery
Issue number11
StatePublished - Nov 1989
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology


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