Calorie restriction alleviates the age-related decrease in neural progenitor cell division in the aging brain

June Hee Park, Zachary Glass, Kasim Sayed, Tatyana V. Michurina, Alexander Lazutkin, Olga Mineyeva, Dmitry Velmeshev, Walter F. Ward, Arlan Richardson, Grigori Enikolopov

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Production of new neurons from stem cells is important for cognitive function, and the reduction of neurogenesis in the aging brain may contribute to the accumulation of age-related cognitive deficits. Restriction of calorie intake and prolonged treatment with rapamycin have been shown to extend the lifespan of animals and delay the onset of the age-related decline in tissue and organ function. Using a reporter line in which neural stem and progenitor cells are marked by the expression of green fluorescent protein (GFP), we examined the effect of prolonged exposure to calorie restriction (CR) or rapamycin on hippocampal neural stem and progenitor cell proliferation in aging mice. We showed that CR increased the number of dividing cells in the dentate gyrus of female mice. The majority of these cells corresponded to nestin-GFP-expressing neural stem or progenitor cells; however, this increased proliferative activity of stem and progenitor cells did not result in a significant increase in the number of doublecortin-positive newborn neurons. Our results suggest that restricted calorie intake may increase the number of divisions that neural stem and progenitor cells undergo in the aging brain of females. We examined the response of adult stem and progenitor cells in the hippocampus to an extended period of calorie restriction and rapamycin supplementation by using a reporter mouse line in which expression of GFP marks adult stem and progenitor cells. Upper left image shows the hippocampus of a young (3 weeks) animal for comparison. We found that calorie restriction increases proliferation of neural stem and progenitor cells in aging females.

Original languageEnglish (US)
Pages (from-to)1987-1993
Number of pages7
JournalEuropean Journal of Neuroscience
Volume37
Issue number12
DOIs
StatePublished - Jun 2013

Fingerprint

Cell Division
Stem Cells
Neural Stem Cells
Brain
Sirolimus
Green Fluorescent Proteins
Adult Stem Cells
Hippocampus
Neurons
Nestin
Cell Aging
Neurogenesis
Dentate Gyrus
Age of Onset
Cognition
Cell Count
Cell Proliferation

Keywords

  • Adult neurogenesis
  • Aging
  • Calorie restriction
  • Rapamycin
  • Stem cells

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Park, J. H., Glass, Z., Sayed, K., Michurina, T. V., Lazutkin, A., Mineyeva, O., ... Enikolopov, G. (2013). Calorie restriction alleviates the age-related decrease in neural progenitor cell division in the aging brain. European Journal of Neuroscience, 37(12), 1987-1993. https://doi.org/10.1111/ejn.12249

Calorie restriction alleviates the age-related decrease in neural progenitor cell division in the aging brain. / Park, June Hee; Glass, Zachary; Sayed, Kasim; Michurina, Tatyana V.; Lazutkin, Alexander; Mineyeva, Olga; Velmeshev, Dmitry; Ward, Walter F.; Richardson, Arlan; Enikolopov, Grigori.

In: European Journal of Neuroscience, Vol. 37, No. 12, 06.2013, p. 1987-1993.

Research output: Contribution to journalArticle

Park, JH, Glass, Z, Sayed, K, Michurina, TV, Lazutkin, A, Mineyeva, O, Velmeshev, D, Ward, WF, Richardson, A & Enikolopov, G 2013, 'Calorie restriction alleviates the age-related decrease in neural progenitor cell division in the aging brain', European Journal of Neuroscience, vol. 37, no. 12, pp. 1987-1993. https://doi.org/10.1111/ejn.12249
Park, June Hee ; Glass, Zachary ; Sayed, Kasim ; Michurina, Tatyana V. ; Lazutkin, Alexander ; Mineyeva, Olga ; Velmeshev, Dmitry ; Ward, Walter F. ; Richardson, Arlan ; Enikolopov, Grigori. / Calorie restriction alleviates the age-related decrease in neural progenitor cell division in the aging brain. In: European Journal of Neuroscience. 2013 ; Vol. 37, No. 12. pp. 1987-1993.
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