TY - JOUR
T1 - Caloric restriction, resveratrol and melatonin
T2 - Role of SIRT1 and implications for aging and related-diseases
AU - Ramis, Margarita R.
AU - Esteban, Susana
AU - Miralles, Antonio
AU - Tan, Dun Xian
AU - Reiter, Russel J.
N1 - Funding Information:
The author M.R. Ramis was supported by a predoctoral FPU fellowship from The Spanish Ministry of Education, Culture and Sport (AP2010-4798 and Est13/00970).
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Aging is an inevitable and multifactorial biological process. Free radicals have been implicated in aging processes; it is hypothesized that they cause cumulative oxidative damage to crucial macromolecules and are responsible for failure of multiple physiological mechanisms. However, recent investigations have also suggested that free radicals can act as modulators of several signaling pathways such as those related to sirtuins. Caloric restriction is a non-genetic manipulation that extends lifespan of several species and improves healthspan; the belief that many of these benefits are due to the induction of sirtuins has led to the search for sirtuin activators, especially sirtuin 1, the most studied. Resveratrol, a polyphenol found in red grapes, was first known for its antioxidant and antifungal properties, and subsequently has been reported several biological effects, including the activation of sirtuins. Endogenously-produced melatonin, a powerful free radical scavenger, declines with age and its loss contributes to degenerative conditions of aging. Recently, it was reported that melatonin also activates sirtuins, in addition to other functions, such as regulator of circadian rhythms or anti-inflammatory properties. The fact that melatonin and resveratrol are present in various foods, exhibiting possible synergistic effects, suggests the use of dietary ingredients to promote health and longevity.
AB - Aging is an inevitable and multifactorial biological process. Free radicals have been implicated in aging processes; it is hypothesized that they cause cumulative oxidative damage to crucial macromolecules and are responsible for failure of multiple physiological mechanisms. However, recent investigations have also suggested that free radicals can act as modulators of several signaling pathways such as those related to sirtuins. Caloric restriction is a non-genetic manipulation that extends lifespan of several species and improves healthspan; the belief that many of these benefits are due to the induction of sirtuins has led to the search for sirtuin activators, especially sirtuin 1, the most studied. Resveratrol, a polyphenol found in red grapes, was first known for its antioxidant and antifungal properties, and subsequently has been reported several biological effects, including the activation of sirtuins. Endogenously-produced melatonin, a powerful free radical scavenger, declines with age and its loss contributes to degenerative conditions of aging. Recently, it was reported that melatonin also activates sirtuins, in addition to other functions, such as regulator of circadian rhythms or anti-inflammatory properties. The fact that melatonin and resveratrol are present in various foods, exhibiting possible synergistic effects, suggests the use of dietary ingredients to promote health and longevity.
KW - Aging
KW - Caloric restriction
KW - Melatonin
KW - Resveratrol
KW - Sirtuins
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UR - http://www.scopus.com/inward/citedby.url?scp=84961289051&partnerID=8YFLogxK
U2 - 10.1016/j.mad.2015.03.008
DO - 10.1016/j.mad.2015.03.008
M3 - Review article
C2 - 25824609
AN - SCOPUS:84961289051
VL - 146-148
SP - 28
EP - 41
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
SN - 0047-6374
ER -