Caloric restriction impedes age-related decline of mitochondrial function and neuronal activity

Ai Ling Lin, Daniel Coman, Lihong Jiang, Douglas L. Rothman, Fahmeed Hyder

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Caloric restriction (CR) prolongs lifespan and retards many detrimental effects of aging, but its effect on brain mitochondrial function and neuronal activityespecially in healthy agingremains unexplored. Here we measured rates of neuronal glucose oxidation and glutamate-glutamine neurotransmitter cycling in young control, old control (i.e., healthy aging), and old CR rats using in vivo nuclear magnetic resonance spectroscopy. We found that, compared with the young control, neuronal energy production and neurotransmission rates were significantly reduced in healthy aging, but were preserved in old CR rats. The results suggest that CR mitigated the age-related deceleration of brain physiology.

Original languageEnglish (US)
Pages (from-to)1440-1443
Number of pages4
JournalJournal of Cerebral Blood Flow and Metabolism
Volume34
Issue number9
DOIs
StatePublished - Sep 2014

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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