Calebin-A induces apoptosis and modulates MAPK family activity in drug resistant human gastric cancer cells

Yan Li; Shaoqing Li; Yueheng Han; Junye Liu; Jian Zhang; Fuyang Li; Yun Wang; Xinping Liu; Libo Yao

doi:10.1016/j.ejphar.2008.06.065

Calebin-A induces apoptosis and modulates MAPK family activity in drug resistant human gastric cancer cells

Yan Li, Shaoqing Li, Yueheng Han, Junye Liu, Jian Zhang, Fuyang Li, Yun Wang, Xinping Liu, Libo Yao

Greehey Children's Cancer Research Institute

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

This study is the first to investigate Calebin-A, a natural compound present in Curcuma longa, which inhibits cell growth and induce apoptosis in SGC7901/VINCRISTINE cells, a multidrug resistant (MDR) human gastric adenocarcinoma cell line. Our data suggest the drug efflux function of P-glycoprotein was inhibited by Calebin-A treatment, while the expression level of P-glycoprotein was not affected. Additionally, co-treatment of Calebin-A and vincristine resulted in a remarkable reduction in S phase and G2/M phase arrest in SGC7901/VINCRISTINE cells. Calebin-A was also found to modulate the activities of mitogen-activated protein kinase (MAPK) family members, which includes decreased c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and increased protein kinase of 38 kDa (p38) activity. These results suggest that Calebin-A might be an effective compound for the treatment of human gastric and other MDR cancers.

Original language	English (US)
Pages (from-to)	252-258
Number of pages	7
Journal	European Journal of Pharmacology
Volume	591
Issue number	1-3
DOIs	https://doi.org/10.1016/j.ejphar.2008.06.065
State	Published - Sep 4 2008

Keywords

Apoptosis
Calebin-A
Curcuma longa
MAPK
MDR
P-glycoprotein

ASJC Scopus subject areas

Pharmacology

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10.1016/j.ejphar.2008.06.065

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title = "Calebin-A induces apoptosis and modulates MAPK family activity in drug resistant human gastric cancer cells",

abstract = "This study is the first to investigate Calebin-A, a natural compound present in Curcuma longa, which inhibits cell growth and induce apoptosis in SGC7901/VINCRISTINE cells, a multidrug resistant (MDR) human gastric adenocarcinoma cell line. Our data suggest the drug efflux function of P-glycoprotein was inhibited by Calebin-A treatment, while the expression level of P-glycoprotein was not affected. Additionally, co-treatment of Calebin-A and vincristine resulted in a remarkable reduction in S phase and G2/M phase arrest in SGC7901/VINCRISTINE cells. Calebin-A was also found to modulate the activities of mitogen-activated protein kinase (MAPK) family members, which includes decreased c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and increased protein kinase of 38 kDa (p38) activity. These results suggest that Calebin-A might be an effective compound for the treatment of human gastric and other MDR cancers.",

keywords = "Apoptosis, Calebin-A, Curcuma longa, MAPK, MDR, P-glycoprotein",

author = "Yan Li and Shaoqing Li and Yueheng Han and Junye Liu and Jian Zhang and Fuyang Li and Yun Wang and Xinping Liu and Libo Yao",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China (30170465, 30228012), Military Research Foundation of China (06G092) and Program for Changjiang Scholars and Innovative Research Team in University (IRT0459). We appreciate the helpful discussion given by Dr. Qiang Yu (Shanghai Institute of Materia Medica, Chinese Academy of Sciences).",

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language = "English (US)",

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T1 - Calebin-A induces apoptosis and modulates MAPK family activity in drug resistant human gastric cancer cells

AU - Li, Yan

AU - Li, Shaoqing

AU - Han, Yueheng

AU - Liu, Junye

AU - Zhang, Jian

AU - Li, Fuyang

AU - Wang, Yun

AU - Liu, Xinping

AU - Yao, Libo

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (30170465, 30228012), Military Research Foundation of China (06G092) and Program for Changjiang Scholars and Innovative Research Team in University (IRT0459). We appreciate the helpful discussion given by Dr. Qiang Yu (Shanghai Institute of Materia Medica, Chinese Academy of Sciences).

PY - 2008/9/4

Y1 - 2008/9/4

N2 - This study is the first to investigate Calebin-A, a natural compound present in Curcuma longa, which inhibits cell growth and induce apoptosis in SGC7901/VINCRISTINE cells, a multidrug resistant (MDR) human gastric adenocarcinoma cell line. Our data suggest the drug efflux function of P-glycoprotein was inhibited by Calebin-A treatment, while the expression level of P-glycoprotein was not affected. Additionally, co-treatment of Calebin-A and vincristine resulted in a remarkable reduction in S phase and G2/M phase arrest in SGC7901/VINCRISTINE cells. Calebin-A was also found to modulate the activities of mitogen-activated protein kinase (MAPK) family members, which includes decreased c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and increased protein kinase of 38 kDa (p38) activity. These results suggest that Calebin-A might be an effective compound for the treatment of human gastric and other MDR cancers.

AB - This study is the first to investigate Calebin-A, a natural compound present in Curcuma longa, which inhibits cell growth and induce apoptosis in SGC7901/VINCRISTINE cells, a multidrug resistant (MDR) human gastric adenocarcinoma cell line. Our data suggest the drug efflux function of P-glycoprotein was inhibited by Calebin-A treatment, while the expression level of P-glycoprotein was not affected. Additionally, co-treatment of Calebin-A and vincristine resulted in a remarkable reduction in S phase and G2/M phase arrest in SGC7901/VINCRISTINE cells. Calebin-A was also found to modulate the activities of mitogen-activated protein kinase (MAPK) family members, which includes decreased c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and increased protein kinase of 38 kDa (p38) activity. These results suggest that Calebin-A might be an effective compound for the treatment of human gastric and other MDR cancers.

KW - Apoptosis

KW - Calebin-A

KW - Curcuma longa

KW - MAPK

KW - MDR

KW - P-glycoprotein

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Calebin-A induces apoptosis and modulates MAPK family activity in drug resistant human gastric cancer cells

Abstract

Keywords

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