Calebin-A induces apoptosis and modulates MAPK family activity in drug resistant human gastric cancer cells

Yan Li, Shaoqing Li, Yueheng Han, Junye Liu, Jian Zhang, Fuyang Li, Yun Wang, Xinping Liu, Libo Yao

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

This study is the first to investigate Calebin-A, a natural compound present in Curcuma longa, which inhibits cell growth and induce apoptosis in SGC7901/VINCRISTINE cells, a multidrug resistant (MDR) human gastric adenocarcinoma cell line. Our data suggest the drug efflux function of P-glycoprotein was inhibited by Calebin-A treatment, while the expression level of P-glycoprotein was not affected. Additionally, co-treatment of Calebin-A and vincristine resulted in a remarkable reduction in S phase and G2/M phase arrest in SGC7901/VINCRISTINE cells. Calebin-A was also found to modulate the activities of mitogen-activated protein kinase (MAPK) family members, which includes decreased c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and increased protein kinase of 38 kDa (p38) activity. These results suggest that Calebin-A might be an effective compound for the treatment of human gastric and other MDR cancers.

Original languageEnglish (US)
Pages (from-to)252-258
Number of pages7
JournalEuropean Journal of Pharmacology
Volume591
Issue number1-3
DOIs
StatePublished - Sep 4 2008

Keywords

  • Apoptosis
  • Calebin-A
  • Curcuma longa
  • MAPK
  • MDR
  • P-glycoprotein

ASJC Scopus subject areas

  • Pharmacology

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