Calcium supplementation modifies the relative amounts of bile acids in bile and affects key aspects of human colon physiology

Joahne R. Lupton, Gideon Steinbach, Wen Chi Chang, Barbara C. O'Brien, Stella Wiese, Cynthia L. Stoltzfus, Gary A. Glober, Michael J Wargovich, R. Sue McPherson, Rodger J. Winn

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Use of calcium supplements has increased dramatically in recent years yet little is known about the effect of calcium supplementation on colon physiology. We supplemented 22 individuals with a history of resected adenocarcinoma of the colon, but currently free of cancer, with 2000 or 3000 mg calcium for 16 wk. The effects of supplementation on duodenal bile acids and important fecal characteristics including total fetal output, wet and dry weight, pH, bile acids (in solids and in fecal water), and concentrations and total excretion of calcium, magnesium, phosphates (organic and inorganic), unesterified fatty acids and total fat were determined. Calcium supplementation significantly decreased the proportion of water in the stool (P = 0.03), doubled fecal excretion of calcium (P = 0.006), and increased excretion of organic phosphate (P = 0.035) but not magnesium. Calcium supplementation significantly decreased the proportion of chenodeoxycholic acid in bile (P = 0.007) and decreased the ratio of lithocholate to deoxycholate in feces (P = 0.06). The concentration of primary bile acids in fecal water decreased after 16 wk Ca supplementation. Together with other reports of a 'healthier' bile acid profile with respect to colon cancer when changes such as those observed in this study were achieved, these results suggest a protective effect of calcium supplementation against this disease.

Original languageEnglish (US)
Pages (from-to)1421-1428
Number of pages8
JournalJournal of Nutrition
Volume126
Issue number5
StatePublished - May 1996
Externally publishedYes

Fingerprint

bile acids
bile
Bile Acids and Salts
Bile
colon
Colon
physiology
Calcium
calcium
excretion
Water
Lithocholic Acid
Chenodeoxycholic Acid
inorganic acids
chenodeoxycholic acid
deoxycholic acid
magnesium phosphates
Deoxycholic Acid
Organophosphates
water

Keywords

  • calcium supplementation
  • chenodeoxycholic acid
  • colon physiology
  • humans
  • lithocholate

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Lupton, J. R., Steinbach, G., Chang, W. C., O'Brien, B. C., Wiese, S., Stoltzfus, C. L., ... Winn, R. J. (1996). Calcium supplementation modifies the relative amounts of bile acids in bile and affects key aspects of human colon physiology. Journal of Nutrition, 126(5), 1421-1428.

Calcium supplementation modifies the relative amounts of bile acids in bile and affects key aspects of human colon physiology. / Lupton, Joahne R.; Steinbach, Gideon; Chang, Wen Chi; O'Brien, Barbara C.; Wiese, Stella; Stoltzfus, Cynthia L.; Glober, Gary A.; Wargovich, Michael J; McPherson, R. Sue; Winn, Rodger J.

In: Journal of Nutrition, Vol. 126, No. 5, 05.1996, p. 1421-1428.

Research output: Contribution to journalArticle

Lupton, JR, Steinbach, G, Chang, WC, O'Brien, BC, Wiese, S, Stoltzfus, CL, Glober, GA, Wargovich, MJ, McPherson, RS & Winn, RJ 1996, 'Calcium supplementation modifies the relative amounts of bile acids in bile and affects key aspects of human colon physiology', Journal of Nutrition, vol. 126, no. 5, pp. 1421-1428.
Lupton JR, Steinbach G, Chang WC, O'Brien BC, Wiese S, Stoltzfus CL et al. Calcium supplementation modifies the relative amounts of bile acids in bile and affects key aspects of human colon physiology. Journal of Nutrition. 1996 May;126(5):1421-1428.
Lupton, Joahne R. ; Steinbach, Gideon ; Chang, Wen Chi ; O'Brien, Barbara C. ; Wiese, Stella ; Stoltzfus, Cynthia L. ; Glober, Gary A. ; Wargovich, Michael J ; McPherson, R. Sue ; Winn, Rodger J. / Calcium supplementation modifies the relative amounts of bile acids in bile and affects key aspects of human colon physiology. In: Journal of Nutrition. 1996 ; Vol. 126, No. 5. pp. 1421-1428.
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