Calcium signaling and apoptosis

György Hajnóczky, Erika Davies, Muniswamy Madesh

Research output: Contribution to journalArticlepeer-review

369 Scopus citations

Abstract

Ca2+ is one of the key regulators of cell survival, but Ca2+ can also induce apoptosis in response to a variety of pathological conditions. The pro-apoptotic effects of Ca2+ are mediated by a diverse range of Ca2+-sensitive factors that are compartmentalized in various intracellular organelles including the ER, cytoplasm, and mitochondria. The Ca2+ dynamics of these organelles appear to be modulated by the apoptosis-regulating Bcl-2 family proteins. In this paper, the recent progress of research on the mechanisms mediating the apoptosis-regulating effects of Ca2+ and the interactions of Bcl-2 family proteins with the Ca2+ storage organelles are discussed.

Original languageEnglish (US)
Pages (from-to)445-454
Number of pages10
JournalBiochemical and Biophysical Research Communications
Volume304
Issue number3
DOIs
StatePublished - May 9 2003
Externally publishedYes

Keywords

  • Apoptosis
  • Bcl-2
  • Bid
  • Calcium signaling
  • Cardiolipin
  • Mitochondria
  • ROS
  • VDAC

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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