Calcium signaling and apoptosis

György Hajnóczky; Erika Davies; Muniswamy Madesh

doi:10.1016/S0006-291X(03)00616-8

Calcium signaling and apoptosis

György Hajnóczky, Erika Davies, Muniswamy Madesh

Research output: Contribution to journal › Article › peer-review

410 Scopus citations

Abstract

Ca²⁺ is one of the key regulators of cell survival, but Ca²⁺ can also induce apoptosis in response to a variety of pathological conditions. The pro-apoptotic effects of Ca²⁺ are mediated by a diverse range of Ca²⁺-sensitive factors that are compartmentalized in various intracellular organelles including the ER, cytoplasm, and mitochondria. The Ca²⁺ dynamics of these organelles appear to be modulated by the apoptosis-regulating Bcl-2 family proteins. In this paper, the recent progress of research on the mechanisms mediating the apoptosis-regulating effects of Ca²⁺ and the interactions of Bcl-2 family proteins with the Ca²⁺ storage organelles are discussed.

Original language	English (US)
Pages (from-to)	445-454
Number of pages	10
Journal	Biochemical and Biophysical Research Communications
Volume	304
Issue number	3
DOIs	https://doi.org/10.1016/S0006-291X(03)00616-8
State	Published - May 9 2003
Externally published	Yes

Keywords

Apoptosis
Bcl-2
Bid
Calcium signaling
Cardiolipin
Mitochondria
ROS
VDAC

ASJC Scopus subject areas

Molecular Biology
Biophysics
Biochemistry
Cell Biology

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10.1016/S0006-291X(03)00616-8

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AU - Hajnóczky, György

AU - Davies, Erika

AU - Madesh, Muniswamy

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AB - Ca2+ is one of the key regulators of cell survival, but Ca2+ can also induce apoptosis in response to a variety of pathological conditions. The pro-apoptotic effects of Ca2+ are mediated by a diverse range of Ca2+-sensitive factors that are compartmentalized in various intracellular organelles including the ER, cytoplasm, and mitochondria. The Ca2+ dynamics of these organelles appear to be modulated by the apoptosis-regulating Bcl-2 family proteins. In this paper, the recent progress of research on the mechanisms mediating the apoptosis-regulating effects of Ca2+ and the interactions of Bcl-2 family proteins with the Ca2+ storage organelles are discussed.

KW - Apoptosis

KW - Bcl-2

KW - Bid

KW - Calcium signaling

KW - Cardiolipin

KW - Mitochondria

KW - ROS

KW - VDAC

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Calcium signaling and apoptosis

Abstract

Keywords

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