TY - JOUR
T1 - Calcium Antagonists in the Treatment of Individuals with Ischemic Heart Disease
AU - Winniford, Michael D.
AU - Willerson, James T.
AU - Hillis, L. David
PY - 1982/8
Y1 - 1982/8
N2 - The so-called calcium antagonists—verapamil, nifedipine, diltiazem, and perhexiline—are pharmacologic agents that will have a dramatic impact on the medical therapy of individuals with ischemic heart disease. They have been used extensively in Europe and Japan for over 15 years, and more recent studies from this country have demonstrated their efficacy in the treatment of patients with Prinzmetal's “variant” angina pectoris, stable (exertional) an gina pectoris, and unstable angina pectoris. In addition, they appear effective in protecting ischemic myocardium both in patients with acute myocardial infarction as well as in those undergoing cardiopulmonary bypass. The purpose of this review is twofold: (a) to describe the mechanism of action and phar macology of these agents and (b) to delineate their role in the treatment of individuals with ischemic heart disease.
AB - The so-called calcium antagonists—verapamil, nifedipine, diltiazem, and perhexiline—are pharmacologic agents that will have a dramatic impact on the medical therapy of individuals with ischemic heart disease. They have been used extensively in Europe and Japan for over 15 years, and more recent studies from this country have demonstrated their efficacy in the treatment of patients with Prinzmetal's “variant” angina pectoris, stable (exertional) an gina pectoris, and unstable angina pectoris. In addition, they appear effective in protecting ischemic myocardium both in patients with acute myocardial infarction as well as in those undergoing cardiopulmonary bypass. The purpose of this review is twofold: (a) to describe the mechanism of action and phar macology of these agents and (b) to delineate their role in the treatment of individuals with ischemic heart disease.
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U2 - 10.1177/000331978203300804
DO - 10.1177/000331978203300804
M3 - Article
C2 - 6287889
AN - SCOPUS:0019968186
VL - 33
SP - 522
EP - 539
JO - Angiology
JF - Angiology
SN - 0003-3197
IS - 8
ER -