Calcium and the muscarinic receptor

M. K. Ticku, D. J. Triggle

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Pharmacological receptors may be viewed as composed of two linked functions, a recognition site through which the specificity and selectivity of ligand action is expressed and an amplification or catalytic site which translates the ligand-recognition site interaction into response. The successful elucidation of receptor mechanisms requires analysis of both sites. The muscarinic cholinergic receptors of guinea-pig ileal longitudinal smooth muscle will be discussed from this two function stand point and the source and utilization of Ca2+ in excitation-contraction coupling discussed.

Original languageEnglish (US)
Pages (from-to)133-140
Number of pages8
JournalGeneral Pharmacology
Issue number2-3
StatePublished - Aug 1976
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology


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