Calcium and the muscarinic receptor

M. K. Ticku; D. J. Triggle

doi:10.1016/0306-3623(76)90049-5

Calcium and the muscarinic receptor

M. K. Ticku, D. J. Triggle

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Pharmacological receptors may be viewed as composed of two linked functions, a recognition site through which the specificity and selectivity of ligand action is expressed and an amplification or catalytic site which translates the ligand-recognition site interaction into response. The successful elucidation of receptor mechanisms requires analysis of both sites. The muscarinic cholinergic receptors of guinea-pig ileal longitudinal smooth muscle will be discussed from this two function stand point and the source and utilization of Ca²⁺ in excitation-contraction coupling discussed.

Original language	English (US)
Pages (from-to)	133-140
Number of pages	8
Journal	General Pharmacology
Volume	7
Issue number	2-3
DOIs	https://doi.org/10.1016/0306-3623(76)90049-5
State	Published - Aug 1976
Externally published	Yes

ASJC Scopus subject areas

Pharmacology

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10.1016/0306-3623(76)90049-5

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title = "Calcium and the muscarinic receptor",

abstract = "Pharmacological receptors may be viewed as composed of two linked functions, a recognition site through which the specificity and selectivity of ligand action is expressed and an amplification or catalytic site which translates the ligand-recognition site interaction into response. The successful elucidation of receptor mechanisms requires analysis of both sites. The muscarinic cholinergic receptors of guinea-pig ileal longitudinal smooth muscle will be discussed from this two function stand point and the source and utilization of Ca2+ in excitation-contraction coupling discussed.",

author = "Ticku, {M. K.} and Triggle, {D. J.}",

note = "Funding Information: Acknowledgements--This work was supported by a grant from the U.S. Public Health Service (HL 16003).",

year = "1976",

month = aug,

doi = "10.1016/0306-3623(76)90049-5",

language = "English (US)",

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journal = "Vascular Pharmacology",

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T1 - Calcium and the muscarinic receptor

AU - Ticku, M. K.

AU - Triggle, D. J.

N1 - Funding Information: Acknowledgements--This work was supported by a grant from the U.S. Public Health Service (HL 16003).

PY - 1976/8

Y1 - 1976/8

N2 - Pharmacological receptors may be viewed as composed of two linked functions, a recognition site through which the specificity and selectivity of ligand action is expressed and an amplification or catalytic site which translates the ligand-recognition site interaction into response. The successful elucidation of receptor mechanisms requires analysis of both sites. The muscarinic cholinergic receptors of guinea-pig ileal longitudinal smooth muscle will be discussed from this two function stand point and the source and utilization of Ca2+ in excitation-contraction coupling discussed.

AB - Pharmacological receptors may be viewed as composed of two linked functions, a recognition site through which the specificity and selectivity of ligand action is expressed and an amplification or catalytic site which translates the ligand-recognition site interaction into response. The successful elucidation of receptor mechanisms requires analysis of both sites. The muscarinic cholinergic receptors of guinea-pig ileal longitudinal smooth muscle will be discussed from this two function stand point and the source and utilization of Ca2+ in excitation-contraction coupling discussed.

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JO - Vascular Pharmacology

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ER -

Calcium and the muscarinic receptor

Abstract

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