The effect of oral supplements of phosphate on mouse colonic epithelial proliferation was investigated. Proliferative activity, measured both by tritiated thymidine uptake and ornithine decarboxylase activity, was increased in mice receiving an intracolonic instillation of deoxycholic acid (DCA); pretreatment of mice by oral intubation of calcium lactate significantly reduced DCA's proliferative effect. However, the hypoproliferative effect of calcium was offset by oral co-administration of Na2HPO4. The results suggest that dietary phosphate, even in excess does not itself significantly stimulate colonic epithelial proliferation, but it may be a factor in blocking the beneficial effect of calcium by reducing colonic epithelial proliferation stimulated by free bile acids.
- cellular proliferation
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics