Calcium and Inorganic Phosphorus Metabolism in Naked Mole Rats Heterocephalus glaber Is Only Indirectly Affected by Cholecalciferol

Shlomo Yahav, Rochelle Buffenstein, John M. Pettifor

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Original languageEnglish
Pages (from-to)161-166
Number of pages6
JournalGeneral and Comparative Endocrinology
Volume89
Issue number1
DOIs
StatePublished - Jan 1993
Externally publishedYes

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Mole Rats
Heterocephalus glaber
cholecalciferol
Cholecalciferol
inorganic phosphorus
Phosphorus
Calcium
calcium
metabolism
Minerals
minerals
excretion
mineral metabolism
intestinal absorption
food intake
mouth
digestive system
Eating
Pathology

ASJC Scopus subject areas

  • Endocrinology

Cite this

Calcium and Inorganic Phosphorus Metabolism in Naked Mole Rats Heterocephalus glaber Is Only Indirectly Affected by Cholecalciferol. / Yahav, Shlomo; Buffenstein, Rochelle; Pettifor, John M.

In: General and Comparative Endocrinology, Vol. 89, No. 1, 01.1993, p. 161-166.

Research output: Contribution to journalArticle

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title = "Calcium and Inorganic Phosphorus Metabolism in Naked Mole Rats Heterocephalus glaber Is Only Indirectly Affected by Cholecalciferol",
abstract = "Naked mole rats seem to be naturally deficient in cholecalciferol yet exhibit net calcium and inorganic phosphorus absorption efficiencies that approach a physiological maximum (i.e., exceed 94{\%}). Oral supplementation with cholecalciferol therefore does not markedly enhance the efficiency of gastrointestinal absorption of these minerals, but rather exerts indirect effects on mineral metabolism by increasing food intake (1.7 ×) from 3.6 ± 0.4 to 6.2 ± 0.3 g/100 g body wt day -1. This, in turn, results in a concomitant increase in the daily rate of calcium absorption from 2.9 ± 0.3 to 4.4 ± 0.4 (mmol/100 g body wt day-1) and inorganic phosphorus absorption from 4.5 ± 0.4 to 7.9 ± 0.4 (mmol/100 g body wt day-1) with cholecalciferol supplementation. Excretion of calcium decreases from 2.9 ± 0.5 to 1.2 ± 0.4 μmol/100 g body wt day-1 with cholecalciferol supplementation whereas inorganic phosphorus excretion is unchanged (4.3 ± 0.9 to 4.3 ± 1.2 μmol/100 g body wt day-1), to give a positive mineral balance, without any evident pathology. Indeed serum calcium (2.3 ± 0.1 vs 2.5 ± 0.1 mmol/liter) and inorganic phosphorus (1.5 ± 0.3 vs 1.6 ± 0.2 mmol/liter) concentrations remain tightly regulated irrespective of vitamin D3 status. Mineral balance in naked mole rats is concluded not to he directly influenced by cholecalciferol, rather it may be affected by pleiotropic actions of cholecalciferol on gut function.",
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N2 - Naked mole rats seem to be naturally deficient in cholecalciferol yet exhibit net calcium and inorganic phosphorus absorption efficiencies that approach a physiological maximum (i.e., exceed 94%). Oral supplementation with cholecalciferol therefore does not markedly enhance the efficiency of gastrointestinal absorption of these minerals, but rather exerts indirect effects on mineral metabolism by increasing food intake (1.7 ×) from 3.6 ± 0.4 to 6.2 ± 0.3 g/100 g body wt day -1. This, in turn, results in a concomitant increase in the daily rate of calcium absorption from 2.9 ± 0.3 to 4.4 ± 0.4 (mmol/100 g body wt day-1) and inorganic phosphorus absorption from 4.5 ± 0.4 to 7.9 ± 0.4 (mmol/100 g body wt day-1) with cholecalciferol supplementation. Excretion of calcium decreases from 2.9 ± 0.5 to 1.2 ± 0.4 μmol/100 g body wt day-1 with cholecalciferol supplementation whereas inorganic phosphorus excretion is unchanged (4.3 ± 0.9 to 4.3 ± 1.2 μmol/100 g body wt day-1), to give a positive mineral balance, without any evident pathology. Indeed serum calcium (2.3 ± 0.1 vs 2.5 ± 0.1 mmol/liter) and inorganic phosphorus (1.5 ± 0.3 vs 1.6 ± 0.2 mmol/liter) concentrations remain tightly regulated irrespective of vitamin D3 status. Mineral balance in naked mole rats is concluded not to he directly influenced by cholecalciferol, rather it may be affected by pleiotropic actions of cholecalciferol on gut function.

AB - Naked mole rats seem to be naturally deficient in cholecalciferol yet exhibit net calcium and inorganic phosphorus absorption efficiencies that approach a physiological maximum (i.e., exceed 94%). Oral supplementation with cholecalciferol therefore does not markedly enhance the efficiency of gastrointestinal absorption of these minerals, but rather exerts indirect effects on mineral metabolism by increasing food intake (1.7 ×) from 3.6 ± 0.4 to 6.2 ± 0.3 g/100 g body wt day -1. This, in turn, results in a concomitant increase in the daily rate of calcium absorption from 2.9 ± 0.3 to 4.4 ± 0.4 (mmol/100 g body wt day-1) and inorganic phosphorus absorption from 4.5 ± 0.4 to 7.9 ± 0.4 (mmol/100 g body wt day-1) with cholecalciferol supplementation. Excretion of calcium decreases from 2.9 ± 0.5 to 1.2 ± 0.4 μmol/100 g body wt day-1 with cholecalciferol supplementation whereas inorganic phosphorus excretion is unchanged (4.3 ± 0.9 to 4.3 ± 1.2 μmol/100 g body wt day-1), to give a positive mineral balance, without any evident pathology. Indeed serum calcium (2.3 ± 0.1 vs 2.5 ± 0.1 mmol/liter) and inorganic phosphorus (1.5 ± 0.3 vs 1.6 ± 0.2 mmol/liter) concentrations remain tightly regulated irrespective of vitamin D3 status. Mineral balance in naked mole rats is concluded not to he directly influenced by cholecalciferol, rather it may be affected by pleiotropic actions of cholecalciferol on gut function.

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