Calcium and colon cancer

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Calcium has been hypothesized as being a regulator of cell proliferation in the colon. Epidemiologic studies suggest that ingestion of higher levels of dietary calcium are related to a decreased risk for colon cancer. Short term studies in vitro and in vivo of the proliferative behavior of human and animal colon mucose verify that calcium does modulate proliferative response. Preliminary clinical studies suggest that the hyperproliferative mucosa of patients at high risk for colon cancer, based on proliferation analysis of biopsied mucosa, became decidedly less proliferative when the subjects were given oral calcium. Our studies address the molecular mechanisms by which calcium controls mucosal proliferation and the ways in which tumor cells circumvent this regulation.

Original languageEnglish (US)
Pages (from-to)295-300
Number of pages6
JournalJournal of the American College of Nutrition
Volume7
Issue number4
StatePublished - 1988
Externally publishedYes

Fingerprint

colorectal neoplasms
Colonic Neoplasms
Calcium
calcium
Colon
Mucous Membrane
colon
mucosa
Dietary Calcium
Animal Behavior
risk reduction
Epidemiologic Studies
human behavior
animal behavior
Eating
in vitro studies
epidemiological studies
Cell Proliferation
clinical trials
mouth

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Calcium and colon cancer. / Wargovich, Michael J.

In: Journal of the American College of Nutrition, Vol. 7, No. 4, 1988, p. 295-300.

Research output: Contribution to journalArticle

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