Burning mouth syndrome: A therapeutic approach involving mechanical salivary stimulation

Fabrício T.A. De Souza, Tânia M.P. Amaral, Taĺita P.M. Dos Santos, Evandro N. Abdo, Maria C.F. Aguiar, Antônio L. Teixeira, Arthur M. Kummer, Mauro H.N.G. Abreu, Tarcília A. Silva

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Objective.-The study aimed to evaluate the effects of salivary stimulation therapy on the salivary flow, quality of saliva, and symptoms in patients with burning mouth syndrome (BMS). Background.-BMS is a chronic disorder characterized by a burning sensation. Some reports have proposed a role for saliva in the pathogenesis of BMS. Methods.-Twenty-six BMS patients underwent treatment with salivary mechanical stimulation. Resting and stimulated saliva were collected before and after therapy. Salivary levels of total protein, brain-derived neurotrophic factor, interleukin-10, tumor necrosis factor-a, interleukin-6, and nerve growth factor were assessed before and 90 days after therapy by enzyme-linked immunosorbent assay. Results.-A significant reduction in the burning sensation and number of burning sites as well as an improvement of taste disturbances and xerostomia were observed after therapy.The salivary flow was not significantly modified.However, the therapy resulted in a significant decrease in salivary levels of total protein and an increase of tumor necrosis factor-a. Conclusion.-Salivary mechanical stimulation therapy is effective in reducing clinical symptoms of BMS.

Original languageEnglish (US)
Pages (from-to)1026-1034
Number of pages9
Issue number6
StatePublished - Jun 2012
Externally publishedYes


  • Burning mouth syndrome
  • Cytokines
  • Mechanical salivary stimulation
  • Therapy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Burning mouth syndrome: A therapeutic approach involving mechanical salivary stimulation'. Together they form a unique fingerprint.

Cite this