TY - JOUR
T1 - Burden of Type 2 Diabetes and Associated Cardiometabolic Traits and Their Heritability Estimates in Endogamous Ethnic Groups of India
T2 - Findings From the INDIGENIUS Consortium
AU - Venkatesan, Vettriselvi
AU - Lopez-Alvarenga, Juan Carlos
AU - Arya, Rector
AU - Ramu, Deepika
AU - Koshy, Teena
AU - Ravichandran, Umarani
AU - Ponnala, Amaresh Reddy
AU - Sharma, Surendra K.
AU - Lodha, Sailesh
AU - Sharma, Krishna K.
AU - Shaik, Mahaboob Vali
AU - Resendez, Roy G.
AU - Venugopal, Priyanka
AU - Parthasarathy, R.
AU - Saju, Noelta
AU - Ezeilo, Juliet A.
AU - Bejar, Cynthia
AU - Wander, Gurpreet S.
AU - Ralhan, Sarju
AU - Singh, Jai Rup
AU - Mehra, Narinder K.
AU - Vadlamudi, Raghavendra Rao
AU - Almeida, Marcio
AU - Mummidi, Srinivas
AU - Natesan, Chidambaram
AU - Blangero, John
AU - Medicherla, Krishna M.
AU - Thanikachalam, Sadagopan
AU - Panchatcharam, Thyagarajan Sadras
AU - Kandregula, Dileep Kumar
AU - Gupta, Rajeev
AU - Sanghera, Dharambir K.
AU - Duggirala, Ravindranath
AU - Paul, Solomon F.D.
N1 - Funding Information:
This study is supported by grants from the Indian Council of Medical Research [ICMR] (India) Project: No. 55/6/2/Indo-US/2014-NCD-II and the National Institute of Diabetes and Digestive and Kidney Diseases [NIDDK], National Institutes of Health [NIH] (US) R21 DK105913 and R01 DK082766.
Publisher Copyright:
Copyright © 2022 Venkatesan, Lopez-Alvarenga, Arya, Ramu, Koshy, Ravichandran, Ponnala, Sharma, Lodha, Sharma, Shaik, Resendez, Venugopal, R, Saju, Ezeilo, Bejar, Wander, Ralhan, Singh, Mehra, Vadlamudi, Almeida, Mummidi, Natesan, Blangero, Medicherla, Thanikachalam, Panchatcharam, Kandregula, Gupta, Sanghera, Duggirala and Paul.
PY - 2022/4/14
Y1 - 2022/4/14
N2 - To assess the burden of type 2 diabetes (T2D) and its genetic profile in endogamous populations of India given the paucity of data, we aimed to determine the prevalence of T2D and estimate its heritability using family-based cohorts from three distinct Endogamous Ethnic Groups (EEGs) representing Northern (Rajasthan [Agarwals: AG]) and Southern (Tamil Nadu [Chettiars: CH] and Andhra Pradesh [Reddys: RE]) states of India. For comparison, family-based data collected previously from another North Indian Punjabi Sikh (SI) EEG was used. In addition, we examined various T2D-related cardiometabolic traits and determined their heritabilities. These studies were conducted as part of the Indian Diabetes Genetic Studies in collaboration with US (INDIGENIUS) Consortium. The pedigree, demographic, phenotypic, covariate data and samples were collected from the CH, AG, and RE EEGs. The status of T2D was defined by ADA guidelines (fasting glucose ≥ 126 mg/dl or HbA1c ≥ 6.5% and/or use of diabetes medication/history). The prevalence of T2D in CH (N = 517, families = 21, mean age = 47y, mean BMI = 27), AG (N = 530, Families = 25, mean age = 43y, mean BMI = 27), and RE (N = 500, Families = 22, mean age = 46y, mean BMI = 27) was found to be 33%, 37%, and 36%, respectively, Also, the study participants from these EEGs were found to be at increased cardiometabolic risk (e.g., obesity and prediabetes). Similar characteristics for the SI EEG (N = 1,260, Families = 324, Age = 51y, BMI = 27, T2D = 75%) were obtained previously. We used the variance components approach to carry out genetic analyses after adjusting for covariate effects. The heritability (h2) estimates of T2D in the CH, RE, SI, and AG were found to be 30%, 46%, 54%, and 82% respectively, and statistically significant (P ≤ 0.05). Other T2D related traits (e.g., BMI, lipids, blood pressure) in AG, CH, and RE EEGs exhibited strong additive genetic influences (h2 range: 17% [triglycerides/AG and hs-CRP/RE] - 86% [glucose/non-T2D/AG]). Our findings highlight the high burden of T2D in Indian EEGs with significant and differential additive genetic influences on T2D and related traits.
AB - To assess the burden of type 2 diabetes (T2D) and its genetic profile in endogamous populations of India given the paucity of data, we aimed to determine the prevalence of T2D and estimate its heritability using family-based cohorts from three distinct Endogamous Ethnic Groups (EEGs) representing Northern (Rajasthan [Agarwals: AG]) and Southern (Tamil Nadu [Chettiars: CH] and Andhra Pradesh [Reddys: RE]) states of India. For comparison, family-based data collected previously from another North Indian Punjabi Sikh (SI) EEG was used. In addition, we examined various T2D-related cardiometabolic traits and determined their heritabilities. These studies were conducted as part of the Indian Diabetes Genetic Studies in collaboration with US (INDIGENIUS) Consortium. The pedigree, demographic, phenotypic, covariate data and samples were collected from the CH, AG, and RE EEGs. The status of T2D was defined by ADA guidelines (fasting glucose ≥ 126 mg/dl or HbA1c ≥ 6.5% and/or use of diabetes medication/history). The prevalence of T2D in CH (N = 517, families = 21, mean age = 47y, mean BMI = 27), AG (N = 530, Families = 25, mean age = 43y, mean BMI = 27), and RE (N = 500, Families = 22, mean age = 46y, mean BMI = 27) was found to be 33%, 37%, and 36%, respectively, Also, the study participants from these EEGs were found to be at increased cardiometabolic risk (e.g., obesity and prediabetes). Similar characteristics for the SI EEG (N = 1,260, Families = 324, Age = 51y, BMI = 27, T2D = 75%) were obtained previously. We used the variance components approach to carry out genetic analyses after adjusting for covariate effects. The heritability (h2) estimates of T2D in the CH, RE, SI, and AG were found to be 30%, 46%, 54%, and 82% respectively, and statistically significant (P ≤ 0.05). Other T2D related traits (e.g., BMI, lipids, blood pressure) in AG, CH, and RE EEGs exhibited strong additive genetic influences (h2 range: 17% [triglycerides/AG and hs-CRP/RE] - 86% [glucose/non-T2D/AG]). Our findings highlight the high burden of T2D in Indian EEGs with significant and differential additive genetic influences on T2D and related traits.
KW - Indian population
KW - cardiometabolic traits
KW - epidemiology
KW - family study
KW - genetic epidemiology
KW - heritability
KW - type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85128973012&partnerID=8YFLogxK
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U2 - 10.3389/fendo.2022.847692
DO - 10.3389/fendo.2022.847692
M3 - Article
AN - SCOPUS:85128973012
SN - 1664-2392
VL - 13
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
M1 - 847692
ER -