Bupropion reduces methamphetamine-induced subjective effects and cue-induced craving

Thomas F. Newton, John D. Roache, Richard De La Garza, Timothy Fong, Christopher L. Wallace, Shou Hua Li, Ahmed Elkashef, Nora Chiang, Roberta Kahn

Research output: Contribution to journalArticlepeer-review

122 Scopus citations

Abstract

Bupropion is an antidepressant with stimulant properties, which inhibits the reuptake of dopamine (DA) and norepinepherine, and is purported to enhance DA neurotransmission. Bupropion is considered an appealing candidate medication for the treatment of methamphetamine dependence. The current laboratory study was set forth to assess the impact of bupropion treatment on the subjective effects produced by methamphetamine in the laboratory. We also assessed the effects of bupropion treatment on craving elicited by exposure to videotaped methamphetamine cues. A total of 26 participants were enrolled and 20 completed the entire study (n = 10 placebo and n = 10 bupropion, parallel groups design). Bupropion treatment was associated with reduced ratings of 'any drug effect' (p<0.02), and 'high' (p<0.02) following methamphetamine administration. There was also a significant bupropion-by-cue exposure interaction on General Craving Scale total score (p<0.002), and on the Behavioral Intention subscale (p<0.001). Overall, the data reveal that bupropion reduced acute methamphetamine-induced subjective effects and reduced cue-induced craving. Importantly, these data provide a rationale for the evaluation of bupropion in the treatment of methamphetamine dependence.

Original languageEnglish (US)
Pages (from-to)1537-1544
Number of pages8
JournalNeuropsychopharmacology
Volume31
Issue number7
DOIs
StatePublished - Jul 19 2006

Keywords

  • Addiction
  • Dependence
  • Dopamine
  • Human
  • Norepinepherine

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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